Synthetic & Natural Bionaphthoquinones
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- Indbinding:
- Paperback
- Sideantal:
- 216
- Udgivet:
- 2. Juli 2020
- Størrelse:
- 150x13x220 mm.
- Vægt:
- 340 g.
- 2-3 uger.
- 11. Oktober 2024
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- 1 valgfrit digitalt ugeblad
- 20 timers lytning og læsning
- Adgang til 70.000+ titler
- Ingen binding
Abonnementet koster 75 kr./md.
Ingen binding og kan opsiges når som helst.
Beskrivelse af Synthetic & Natural Bionaphthoquinones
This book is based on naphthoquinones and their biological evaluation for different targets (DNA topoisomerase-I, COX-2, Neuraminidase). Enzyme and cyto-toxicity assay was performed with molecular docking studies. 3, 3¿-(arylmethylene) bis (2-hydroxynaphthalene-1, 4 dione) derivatives were synthesized from lawsone by two methods 1] in presence of LiCl 2] amino acid ester. DNA topoisomerase-I enzyme inhibition studies were conducted with simultaneous and preincubation conditions. Total inhibition compared to Camptothecin as positive control on both the systems of enzyme inhibition systems as well as on Leishmania donovani promastigotes. Diospyrin was isolated in a fairly large quantity from the stem bark of Diospyros montana Roxb.(family: Ebenaceae). Extraction of diospyrin from dried stem bark of Diospyros montana by petroleum ether (60-80) and chloroform in soxhlet apparatus for 2 days. The book describes about the synthetic as well as natural naphthoquinones and their biological evaluation with the help of molecular docking.
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