Bøger i Wiley Series on Mass Spectrometry serien

Mass spectrometry (MS) is the major analytical technology used for protein identification, sequencing, and quantitation, and is central to discoveries in proteomics, and is likely to be a major tool for the study of protein interactions in the coming years.

Provides a comprehensive description of mass spectrometry basics, applications, and perspectives Mass spectrometry is a modern analytical technique, allowing for fast and ultrasensitive detection and identification of chemical species. It can not only serve for analysis of narcotics, counterfeit medicines, components of explosives, but also in clinical chemistry, forensic research and anti-doping analysis, for identification of clinically relevant molecules as biomarkers of various diseases. This book describes everything readers need to know about mass spectrometry--from the instrumentation to the theory and applications. It looks at all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS (paying special attention to various methodologies and data interpretation). It also contains a list of key terms for easier and faster understanding of the material by newcomers to the subject and test questions to assist lecturers. Knowing how crucial it is for young researchers to fully understand both the power of mass spectrometry and the importance of other complementary methodologies, Mass Spectrometry: An Applied Approach teaches that it should be used in conjunction with other techniques such as NMR, pharmacological tests, structural identification, molecular biology, in order to reveal the true function(s) of the identified molecule. Provides a description of mass spectrometry basics, applications and perspectives of the technique Oriented to a broad audience with limited or basic knowledge in mass spectrometry instrumentation, theory, and its applications in order to enhance their competence in this field Covers all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS with special attention to application of various methodologies and data interpretation Includes a list of key terms, and test questions, for easier and faster understanding of the material Mass Spectrometry: An Applied Approach is highly recommended for advanced students, young scientists, and anyone involved in a field that utilizes the technique.

With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists.

Mass spectrometry is a powerful analytical technique used to identify unknown compounds, to quantify known materials, and to elucidate the structural and chemical properties of molecules. Inorganic mass spectrometry focuses on the analysis of metals and elements rather than organic compounds.

The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics.

* Comprehensive chromatography represents one of the most powerful tools in the separation of complex mixtures * The book is both broad covering many areas of techniques and applications while still being focused to a specific topic.

Provides an overview of the use of mass spectrometry (MS) for the analysis of pesticide residues and their metabolites.

* Mass Spectrometry is a major tool to characterize, identify and detect hundreds of known and unknown drugs.

Mass spectrometry (MS) is a crucial method in ensuring the production, quality, and safety of grape, wine, and grape-derivative products. This book concisely presents the applications of mass spectrometry in the analysis of wine, from traditional to more recent developments.

Methodology and applications of redox proteomics The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases.

Illicit drugs are an emerging class of environmental contaminants and mass spectrometry is the technique of choice for their analysis.

A concise and authoritative overview of mass spectrometry instrumentation, techniques, and applications in a very readable, user-friendly format filled with chapter summaries, exercises and answers, and references to useful outside resources. * Includes numerous exercises in every chapter, with the answers at the back of the book.

Principles of Mass Spectrometry Applied to Biomolecules teaches readers how to use what they know about Mass Spectrometry's advantages and limitations to develop novel ways of using the technique for the analysis of proteins and other biomolecules.

The last few years have seen an unprecedented drive toward the application of proteomics to resolving challenging biomedical and biochemical tasks. Separation techniques combined with modern mass spectrometry are playing a central role in this drive. This book discusses the increasingly important role of mass spectrometry in proteomic research, and emphasizes recent advances in the existing technology and describes the advantages and pitfalls as well.* Provides a scientifically valid method for analyzing the approximatey 500,000 proteins that are encoded in the human genome* Explains the hows and whys of using mass spectrometry in proteomic analysis* Brings together the latest approaches combining separation techniques and mass spectrometry and their application in proteome analysis* Comments on future challenges and how they may be addressed* Includes sections on troubleshooting

This volume describes the complete process of analyzing protein sequences by mass spectrometry including sample preparation, analysis, and data interpretation at a practical level. It provides sufficient experimental detail to carry out the experiments and consistently achieve good results.

This book encompasses topics from the fundamentals of disease related protein misfolding and mass spectrometry, to current research highlights in these areas. It is aimed to provide an overview of this rapidly developing field in order to present a good mixture of information that will encourage people to participate in, and further the use of mass spectrometry in studying protein misfolding with biologically relevant applications. Using examples from the current literature, the book focuses on details relating to understanding the fundamentals of disease related protein misfolding, conducting and optimising the mass spectrometry experiment, and also future prospects of methodologies within this rapidly evolving and topical research area.Using current examples and high-quality illustrations, this book covers topics including how to conduct and optimize experiments; the structural and atomic level information afforded by mass spectrometry in disease related protein systems, and incorporates future research prospects.

Provides comprehensive coverage of the interpretation of LC-MS-MS mass spectra of 1300 drugs and pesticides* Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes* This is the reference book for the interpretation of MS-MS mass spectra of small organic molecules* Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others* Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups* Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns

With its detailed and systematic coverage of the current state of biophysical mass spectrometry (MS), here is one of the first systematic presentations of the full experimental array of MS-based techniques used in biophysics, covering both fundamental and practical issues.

Covers the area of lipidomics from fundamentals and theory to applications* Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics* Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids* Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation* Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes