Bøger i Molecular Biology Intelligence Unit serien

This book will be of undoubted value to biomedical students and teachers, as well as those actively engaged in research on cholesterol metabolism, cancer, and atherosclerosis.

The B7-CD28 family molecules are probably the most intensively studied receptor-ligand systems in the field of immunology. This book covers significant territory of this rapidly moving field from structural biology and biochemical signalling to immunological functions and their potential applications in the treatment of human diseases.

Eukaryotic DNA Damage Surveillance and Repair contains chapters from experts in the field of DNA damage detection, repair, and cell cycle control.

Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins.

This book provides information on the molecular interactions between host cell organelles and pathogens, which have developed strategies to survive within infected cells. Host response. Host cells are able to react against intruders and eventually mount host responses.

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Recent advances in genomic sequencing provide the background for analysis of polymorphic sites in large chromosomal regions or even in whole genome, thus providing the tool for effective identification of loci that are under strong pressure of positive selection.

Recent advances in genomic sequencing provide the background for analysis of polymorphic sites in large chromosomal regions or even in whole genome, thus providing the tool for effective identification of loci that are under strong pressure of positive selection.

Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states.

these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. * *- High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules.

The effects of IL-10 in vivo are presented, describing an IL-10 transgenic mouse model, the IL-10 "knock-out" mouse, and the capacity of IL-10 to prevent lethal toxic shock in mice.

This volume aims to extract and summarize all information about CAK by pointing out commonly accepted facts and unresolved issues. It takes the reader from yeast to mammals and describes all areas that CAK is thought to be involved in. any person interested in cell growth, signal transduction and cancer will find this a useful tool to own.

Wnt genes code for a family of secreted glycoproteins which fulfil important functions during the development of vertebrates and invertebrates. This book will be of interest to all professionals in the field of Wnt signaling, signal transduction or animal development.

The purpose of E-Cell System: Basic Concepts and Applications is to provide a comprehensive guide for the E-Cell System version 3 in terms of the software features and its usage.

Wnt genes code for a family of secreted glycoproteins which fulfil important functions during the development of vertebrates and invertebrates. This book will be of interest to all professionals in the field of Wnt signaling, signal transduction or animal development.

This volume provides broad insights to the most recent discoveries in telomere biology, with current applications in tumor diagnostics and future potentials in therapy. This book will be a core reference for any physician, scientist or "educated reader" with an interest in the exciting developments in this research field.

The Cystic Fibrosis Transmembrane Conductance Regulator addresses a select series of `hot' topics that relate to the function of CFTR, and the links between CFTR dysfunction and human disease (i.e., cystic fibrosis).

This book is unique in providing pertinent information on the various established roles carbohydrate play in the immune system and how the innate and adaptive immune systems respond to this type of microbial antigens.

This book is the first comprehensive volume on the "Nramp family", highlighting the physiological importance of Nramp proteins as metal transporters. The Nramp Family will be useful to a broad community of scientists interested in metal transport and molecular biology.

The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell.

Interaction of antigen-antibody complexes with cells via specific immunoglobulin Fc receptors (FcR) triggers major immunological reactions such as efficient uptake of antigen, phagocytosis of microorganisms, cytotoxicity towards tumor or virus infected cells, mast cell degranulation and inflammation, etc. This book reviews the FcR for the different immunoglobulin isotypes, focusing on the structural bases of their biological functions, and on the regulation of their expression in physiology and pathology.

This book addresses the most recent advances in the transport of proteins across a variety of biological membranes.

Since its first discovery in the early 90's, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease.

The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland.

Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.