Parkinson's Disease: From Clinical Aspects to Molecular Basis

Parkinson's disease (PD) refers to a type of long-term degenerative disorder of the central nervous system which primarily impacts the motor system. It is clinically categorized through movement disorders, including tremor, muscular stiffness and akinesia. The study of its molecular and biochemical mechanisms aids in better understanding of the normal brain ageing. The cause of PD is still unknown, but both environmental and inherited factors are assumed to have a role in the disease. A separate set of genes whose dysfunctional regulation is significantly linked to the disease. These genes comprise DJ-1, ATP13A2, alpha-synuclein, PTEN induced putative kinase 1 (PINK1), leucine rich repeat kinase 2 (LRRK2) and parkin. In clinical practice, a range of medications are utilized for treating PD, the majority of which work by raising dopamine levels in the midbrain. This book provides significant information to help develop a good understanding of Parkinson's disease. It aims to shed light on clinical aspects and molecular basis of this disease. This book will serve as a reference to a broad spectrum of readers.