Novel Oxidoreductases for Steroid Reduction

In recent years, enzymes have been recognized as powerful tools for the synthesis and modification of steroids and isoprenoids. This has led to an increasing interest in the study of novel oxidoreductases that are specific to these molecules. In this regard, Anandsukeerthi Sandholu has conducted extensive research on the identification, purification, and characterization of such enzymes. Oxidoreductases are a class of enzymes that catalyze the transfer of electrons from one molecule to another. They play an important role in the reduction of steroids and isoprenoids by selectively catalyzing the oxidation or reduction of specific functional groups. Sandholu's work has focused on understanding the specificity, structure, and function of these enzymes. One of the key aspects of Sandholu's research has been the identification and isolation of novel oxidoreductases from microorganisms. By screening a large number of microorganisms, Sandholu has been able to identify several promising candidates for further study. These enzymes have been purified and characterized, and their substrate specificity has been determined. Sandholu has also studied the structural and functional properties of these enzymes using a variety of techniques such as X-ray crystallography, NMR spectroscopy, and enzyme kinetics. These studies have provided insights into the mechanisms by which these enzymes catalyze the reduction of steroids and isoprenoids. Sandholu's work has important implications for the biocatalytic synthesis of steroids and isoprenoids. Enzymes are increasingly being used as biocatalysts in the production of these molecules, and the identification and characterization of novel oxidoreductases with specificities for different functional groups will enable the development of more efficient and selective biocatalytic processes. In conclusion, Anandsukeerthi Sandholu's research on novel oxidoreductases for steroid reduction has contributed significantly to our understanding of these enzymes and their role in the biocatalytic synthesis of steroids and isoprenoids. Her work has important implications for the development of more efficient and selective biocatalytic processes in the future.