Molecular Basis of Autism

An individual with autism experiences difficulties with social interactions and communication, and exhibits restricted and repetitive behavior. The underlying cause of the disease is not entirely understood but can be ascribed to a combination of genetic and environmental factors. The genetics of autism are complex. The associated behaviors of autism may have multiple pathophysiologies. It does not have a unifying mechanism at the cellular, molecular or systems level, but it is believed that autism may be caused due to converging mutations on common molecular pathways. Autistic children experience faster growth of brain in early stages, followed by relatively slower or normal growth during childhood. This early overgrowth is hypothesized to be due to a disturbed neuronal migration during early gestation, an excess of neurons which causes local overconnectivity in specific brain areas, unbalanced excitatory-inhibitory networks, etc. This book covers in detail some existing theories and innovative concepts revolving around the pathophysiology of autism. It presents researches and studies performed by experts across the globe on the molecular basis of autism. It will help new researchers by foregrounding their knowledge in this domain.