Immunology of Diabetes

Diabetes is a group of metabolic diseases caused by chronic high glucose levels in the blood. In this disease, beta cells (β cells) of the pancreas lose their ability to produce adequate insulin, or there is ineffective utilization of insulin by cells in the body. Type 1 diabetes (T1D) and type 2 diabetes (T2D) are the two prevalent types of diabetes. Type 1 diabetes is an autoimmune disorder in which the immune system attacks and damages the insulin producing beta cells. In type 2 diabetes the body becomes insulin resistant and there is an accumulation of sugar. Insulin resistance that is a result of insulin signaling inhibition leads to a series of immune responses that intensify the inflammatory state, leading to the condition of hyperglycemia. This book includes some of the vital pieces of work being conducted across the world, on various topics related to diabetes and immunology. Its extensive content provides the readers with a thorough understanding of the subject. This book will prove to be immensely beneficial to students and researchers in this field.