Effects of Tualang Honey on Non-Alcoholic Steatohepatitis Rat Model

Non-alcoholic Steatohepatitis (NASH) is a common chronic liver disease that may progress to cirrhosis and hepatocellular carcinoma. Currently, there is limited therapy available. Tualang honey which is known for its anti-inflammatory and anti-oxidative effects may improve NASH as inflammatory process and oxidative damage have been implicated in the pathogenesis. However studies utilizing animal models induced with cholesterol diet ranging from 0.5 ¿ 2% are hampered by inconsistent yield of NASH features as assessed histologically. The aims of this study are to establish NASH animal model utilizing high cholesterol diet and to investigate the effects of Tualang honey on NASH.