Drug Metabolism and Pharmacokinetics
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- Indbinding:
- Hardback
- Sideantal:
- 134
- Udgivet:
- 14. februar 2024
- Størrelse:
- 183x14x260 mm.
- Vægt:
- 494 g.
- 2-3 uger.
- 22. november 2024
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- 1 valgfrit digitalt ugeblad
- 20 timers lytning og læsning
- Adgang til 70.000+ titler
- Ingen binding
Abonnementet koster 75 kr./md.
Ingen binding og kan opsiges når som helst.
Beskrivelse af Drug Metabolism and Pharmacokinetics
This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and
metabolism and elimination half-life, drug¿drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in
pharmacokinetic, metabolomic, and bioanalytical studies.
Key Features:
¿ Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety
evaluations
¿ Depicts experimental and biophysical techniques used in bioanalytical and metabolomic
studies
¿ Summarizes in silico, in vitro, and in vivo methods used in drug¿enzyme interactions, drug¿
drug interactions, and toxicokinetics
Written by a global team of experts, this book is a valuable resource for drug discovery scientists,
drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical
scientists, healthcare professionals, researchers, teaching faculty, and students.
metabolism and elimination half-life, drug¿drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in
pharmacokinetic, metabolomic, and bioanalytical studies.
Key Features:
¿ Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety
evaluations
¿ Depicts experimental and biophysical techniques used in bioanalytical and metabolomic
studies
¿ Summarizes in silico, in vitro, and in vivo methods used in drug¿enzyme interactions, drug¿
drug interactions, and toxicokinetics
Written by a global team of experts, this book is a valuable resource for drug discovery scientists,
drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical
scientists, healthcare professionals, researchers, teaching faculty, and students.
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