Bøger i The Clinics: Internal Medicine serien

Includes topics such as: Genetic Risk and Gynecologic Cancer, Current Management of Preinvasive Cervical Neoplasia, Current Surgical Management of Cervical Neoplasia, Current Surgical Management of Ovarian Cancer, Current Management of Trophoblastic Disease, and New Developments in Radiation Management and Gynecologic Cancers.

Provides the essential updates in food allergies. In this title, topics include: mechanisms of allergic sensitization to foods - bypassing immune tolerance pathways; determinants of food allergenicity; epidemiology of food allergy; prevention of food allergy through manipulating the timing of food exposure; and, food-induced anaphylaxis.

Includes the following topics: Detection of cancer biomarkers by cerium oxide nanoparticles; Quantum dot-based assays for cancer biomarkers; Monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo diagnosis of cancer; RNA quantification with gold nanoprobes for cancer diagnostics; and, more.

Provides essential updates on thyroid disorders and diseases. This title includes topics such as: thyroid synthesis and physiology; hyperthyroidism; hypothyroidism; thyroid nodules; goiter; differentiated thyroid cancer; subacute, silent, and postpartum thyroiditis; thyroid and pregnancy; and, more.

What are the effects of the multitude of media that are available to our children and adolescents? This title includes following topics: Health Effects of Media on Children and Adolescents; What Every Pediatrician Needs to Know About Social Networking Sites; Should Babies Be Watching TV and Videos?; Creative and Prosocial Uses of Media and more.

Pneumonia is the leading cause of death due to infectious disease. This book focuses on the controversies and questions surrounding community-acquired pneumonia. It also discusses how to approach MRSA as a cause of CAP and how to approach the non-responding patient.

The potential etiologies of infection are diverse and these infections can progress rapidly in SOT patients. Diagnosis can be difficult, owing to the altered anatomy that sometimes follows transplant surgery. Many of the areas related to infections in SOT recipients are unresolved and controversial.

This issue of Clinics in Laboratory Medicine, edited by Dr. Steven Billings, will cover Dermatopathology. Topics covered in this issue include Blue nevi and related lesions, sentinel lymph node biopsies in melanoma, Spitzoid melanocytic neoplasms, Tumor immunology related to melanoma, Molecular aspects of melanoma, Merkel cell carcinoma, Cutaneous Squamous Cell Carcinoma, Cutaneous T-cell lymphomas, Cutaneous B-cell lymphomas, Myeloid neoplasms, among others.

This special issue of Heart Failure Clinics examines heart failure with a truly global perspective, exposing health inequities in the treatment of heart failure.

This issue will cover novel approaches to demonstrating value by anesthesiologists. Articles will include Value from the Patient and Payer Perspectives, Perioperative Surgical Home, Demonstrating Value: A British perspective, Demonstrating value: A case study of enhanced recovery, Acute Pain Management/Regional, Measuring Outcomes as Demonstrating Value and many more!

This issue of Clinics in Chest Medicine focuses on Sarciodosis. Drs. Baughman and Culver have put together an expert roster of authors for articles concerning: Etiology of sarcoidosis, Immunology of sarcoidosis, Genetics of Sarcoidosis, Diagnosis of sarcoidosis, Chest imaging, Biomarkers and genetic profiles, Pulmonary Sarcoidosis, Neurosarcoidosis, Cardiac Sarcoidosis, Ocular Sarcoidosis, Quality of life assessments, and more!

This issue of Primary Care: Clinics in Office Practice, Guest Edited by George G.A. Pujalte, MD, is devoted to Primary Care Dermatology. Dr. Pujalte has assembled a group of expert authors to review the following topics: Urticaria and allergy-mediated conditions; Dermatologic manifestations of systemic diseases; Viral skin infections; Fungal skin infections; Bacterial skin infections; Parasitic skin infections; Pressure and friction injuries to the skin; Sunburn, thermal, and chemical injuries to the skin; Acne; Alopecia; Nail deformities and injuries; and Skin cancer.

This issue of Clinics in Geriatric Medicine, guest edited by Dr. Daniel E. Forman, is devoted to Cardiac Rehabilitation. Articles in this outstanding issue include: Cardiac Rehabilitation: No Such Thing As ''Too Old''; Evaluating and Treating Frailty in Cardiac Rehabilitation; Utility of Home-based Cardiac Rehabilitation for Older Adults; Benefits of Smart devices, Wearables, and Other Telehealth Options to Enhance Cardiac Rehab; Resistance Training in Cardiac Rehabilitation for Older Adults; High Intensity Interval Training (HIIT) in Cardiac Rehabilitation for Older Adults; Pre-habilitation: The right medicine for older frail adults anticipating TAVR, CABG, and other cardiovascular care; Using Cardiac Rehabilitation to Adjust Medications in Older Adults: Aggressive Prevention and Deprescribing as 2 Sides of the Same Coin; Gender Disparities in Cardiac Rehabilitation Among Older Women: Key opportunities to improve care; Cardiac Rehabilitation for TAVR; Cardiac Rehabilitation for Heart Failure in Older Adults; Cardiac Rehabilitation for Peripheral Arterial Disease (PAD) in Older Adults; Cardiac Rehabilitation as Part of Management in Post-acute Care (PAC): Opportunities for improving care; and Tailoring Assessments in Cardiac Rehabilitation for Older Adults: The relevance of geriatric domains.

This issue of Immunology and Allergy Clinics, guest edited by Drs. Linda S. Cox and Anna H. Nowak-Wegrzyn, is devoted to Aeroallergen and Food Immunotherapy.  Articles in this issue include History of AIT and the future direction of CRD/molecular allergy; Mechanisms of aeroallergen allergen immunotherapy: SCIT and SLIT; Mechanisms underlying induction of tolerance to foods; Biomarkers for allergen immunotherapy; SCIT and SLIT; Novel delivery routes for allergy immunotherapy; Oral immunotherapy for food allergy; SLIT and EPIT for food allergy; The use of adjuvants for enhancing allergen immunotherapy efficacy; Allergen immunotherapy vaccine modification; Allergen immunotherapy outcome assessment in clinical trials and real life; Component resolved diagnosis: can it make specific AIT more specific?; Baked milk and egg diets for milk and egg allergy management; and Allergen immunotherapy practical considerations: adherence and strategies to improve.

Pediatricians in the Unites States and around the World continue to face a myriad of global health threats affecting child and adolescent health including: 1) infectious diseases of poverty [e.g. human immunodeficiency virus (HIV), tuberculosis, malaria, and neglected tropical diseases] in low-and middle-income countries (LMIC), especially in sub Saharan Africa; 2) emerging and reemerging infectious diseases (such as Ebola); 3) rise of non-communicable diseases (e.g. common mental disorders); 4) unintentional injuries; and 5) environmental health hazards (e.g. climate change). Despite the promising news about rapid declines in maternal and child mortality in the era of Millennium Development Goals (MDGs), which originated from the United Nation (UN) Millennium Declaration in 2000, only 20% and 7% of LMIC are currently on track to attain the maternal and child mortality targets. For example, 44% of deaths in children younger than 5 years occur in neonates. Besides discovery of life-saving interventions (e.g. development of new and improved vaccines) for maternal and child health, we also need to do a better job at bridging the knowledge-implementation gap and increase the effectiveness of proven interventions. For example, despite the availability of effective vaccines to prevent pneumococcal pneumonia, rotavirus gastroenteritis, and human papilloma virus-related diseases (e.g. cervical cancer), use of these vaccines remain suboptimal in LMIC. We need to recognize that global health is also local public health. For example, improving access, equity and quality of care for orphans and vulnerable children, immigrant and newly arrived refugee children in the U.S. remains a challenge. Timely access to psychiatric care for children and adolescents with mental illness is a major concern. The explosion of new age technology (such as the internet) also poses a considerable risk to children and adolescents. Pediatricians also need to be aware of diverse socio-cultural determinants of health and ethical issues in global health service and delivery.This issue of Pediatric Clinics of North America aims to address the above crucial global health challenges affecting children and adolescents. As practicing pediatricians, we have the unique opportunity to influence local and global public health. In the post-MDG era (beyond 2015), collaborative partnerships between various disciplines and across research, education and service is vital to reduce health inequities in children worldwide.

There have been major advances in new therapies, diagnostic tools, and strategies for treatment and prevention of fungal infections. Despite these encouraging developments, large numbers of patients are at risk for infectious diseases, and the epidemiology of invasive mycoses continues to emerge. The diagnosis of these infections remains difficult, and treatment outcomes in highly immunosuppressed patients remain poor. Thus, this issue is devoted to state-of-the-art updates on fungal infections by internationally recognized authorities in this field. Some topics covered are Antifungal agents; State-of-the-art culture, identification, and resistance testing of fungal pathogens; Non-culture diagnostics in fungal disease; Contemporary strategies in the prevention and management of fungal infections; Invasive candidiasis; Invasive aspergillosis; Mucormycoses; and Cryptococcosis to name a few.

The impact of cardiovascular disease on an infant extends from the fetal period to well beyond childhood. Perinatalogists and neonatologists can impact maternal and fetal health through wide range of diagnostic modalities and interventional techniques. For our edition focused on cardiovascular health, we sought to encompass the breadth of knowledge that would be the most relevant for the bed side clinician. Our goal was to assemble contents that would allow a clinician to quickly peruse the journal, and then be prepared to make a medical decision. The interaction between cardiology and perinatology/neonatology includes genetics, diagnostics, interventions, counseling, routine stabilization and day to day care. Ultimately, the goal is to establish the foundation for a healthy adult. For this reason, we have even included chapters on topics that are significant on a day to day basis (such as the proper environment for a newborn) and a long term basis (like the overall neurodevelopmental impact of our interventions). Hopefully, whether in the middle of the night as an emergency reference or during the day as a reliable guide, this edition of Clinics in perinatology will be an important bedside tool for anyone that participates in the care of a patient with perinatal heart disease.

This issue of the Interventional Cardiology Clinics edited by Michael Lee covers all key aspects of complex coronary intervention. Topics include, but are not limited to: Saphenous Vein Interventions, Atherectomy Devices for the Treatment of Calcified Lesions, Bifurcation Stenting, Chronic Total Occlusion, Multivessel Coronary Artery Disease, Management of Complications (Perforation/Dissection/Thrombosis), Antithrombotic Therapy in Percutaneous Coronary Intervention, and Acute Myocardial Infarction/Thrombectomy.

This issue of Endocrinology and Metabolism Clinics examines the timely topic of Lipidology. In addition to the New Recommendations - ACC/AHA Lipid Guidelines, the issue also includes Familial Hypercholesterolemia; LDL Apheresis; Lipids in Pregnancy and Women; Diabetes and Lipidology; Diabetic Dyslipidemia; Fatty Liver Disease; Lipids and HIV Disease; Residual Risk; and Statins' effects on diabetes, cognition, and liver safety.

This issue of Clinics in Geriatric Medicine, guest edited by Drs. Cynthia Boyd, James T. Pacala, and Michael W. Rich, is devoted to Chronic Conditions in Older Adults with Cardiovascular Disease. Articles in this issue include: Epidemiology of multimorbidity in older adults with cardiovascular disease; Impact of multimorbidity on clinical outcomes in older adults with cardiovascular disease; Assessment of goals of care in patients with multiple chronic conditions; Challenges in decision-making: balancing trade-offs; Multimorbidity in older adults with heart failure; Multimorbidity in older adults with acute coronary syndromes; Multimorbidity in older adults with aortic stenosis; Multimorbidity in older adults with atrial fibrillation;Anticoagulation in older adults with multimorbidity; Approach to evaluating the multimorbid patient with cardiovascular disease undergoing non-cardiac surgery; Integrating care across disciplines; Assessing risks and benefits of invasive cardiac procedures in patients with advanced multimorbidity; Multimorbidity and end of life care in patients with cardiovascular disease; and Future research directions for cardiovascular disease.

Preterm neonates remain at increased risk for adverse bilirubin-related outcomes, including acute bilirubin encephalopathy relative to term infants. Yet, most vulnerable neonates are likely benefit form the potent anti-oxidant properties of bilirubin. Evidence-based guidelines for the management of hyperbilirubinemia in preterm infants, however, are lacking. High concentrations of unconjugated bilirubin can cause permanent neurologic damage in infants, evident through magnetic resonance imaging of chronic bilirubin encephalopathy or kernicterus. There is a growing concern that exposures to even moderate concentrations of bilirubin may lead to subtle but permanent neurodevelopmental impairment referred to as bilirubin-induced neurologic dysfunction. Our current use of phototherapy to decrease bilirubin loads and its potential photo-oxidant properties is a biological conundrum that has been questioned in the use of phototherapy for very low birth weight neonates. In this issue of Clinics in Perinatology, we provide updates on the current understanding of the biology, mechanisms of increasing bilirubin load due to hemolysis, decreased bilirubin binding capacity and glucose-6-phosphate dehydrogenase deficiency, as well as clinical strategies to operationalize the thresholds for hyperbilirubinemia interventions in preterm infants.

This issue of the Surgical Pathology Clinics, edited by Drs. Blaise Clarke and Glenn McCluggage, focuses on Gynecologic Pathology. Topics covered in the issue include, but are not limited to: Gynecologic manifestations of the DICER1 syndrome; Prophylactic gynecologic specimens from hereditary cancer carriers; Lynch syndrome associated endometrial cancer; Peutz-jeghers syndrome associated gynecologic tumors; Gynecologic manifestations of less commonly encountered hereditary syndromes; and Clinical testing for hereditary predisposition.

This issue of Dermatologic Clinics, Guest Edited by Dr. Murad Alam, is devoted to Practice Gaps in Dermatology. Articles in this issue include: Psoriasis and Papulosquamous Disorders; Blistering Diseases; Disorders of the Nails; Disorders of the Hair; Infections; Abnormal Pigmentation; Lupus, Scleroderma, Dermatomyositis; Genodermatoses; Pruritus; Drug Reactions; Dermatoses of Pregnancy; Contact Dermatitis; Acne and Rosacea; Radiation Therapy; Surgery for Skin Cancer; Cosmetic Dermatologic Surgery; Light, Laser and Energy Treatments; and Melanocytic Lesions and Melanoma.

This issue of PET Clinics focuses on PET-Based Molecular Imaging in Evolving Personalized Management Design, and is edited by Drs. Abass Alavi and Sandip Basu. Articles will include: PET-Based Personalized Medicine: An Unavoidable Path for the Foreseeable Future; Personalized Management Approaches in Lymphoma: Help from PET; PET-CT in Head-Neck Malignancies: the Implications for Personalized Clinical Practice; PET Imaging of Skeletal Metastases and its Role in Personalising Further Management; PET-Based Molecular Imaging in Designing a Personalized Management Model in Neuroendocrine Tumors; Personalized Clinical Decision Making in GI Malignancies: Where Can PET Help?; PET in Breast Carcinoma: Can it Aid in Developing a Personalized Treatment Design; PET and Thyroid Cancer: Can it Help in Evolving a Personalized Treatment Design?; PET Imaging Towards Individualized Management of Urological and Gynaecological Malignancies; The Possible Role of PET Imaging towards Individualized Management of Bone and Soft Tissue Malignancies; PET-Based Personalized Management of Inflammatory Disorders; PET-Based Radiation Oncology; PET-Based Interventional Radiology; The Current and Evolving Role of PET in Personalized Management of Lung Carcinoma, and more!

This issue of Emergency Medicine Clinics focuses on Geriatric Emergencies. Articles include: Recent Trends in Geriatric Emergency Medicine, Resuscitation of the Elderly, Pharmacology in the Geriatric Patient, Trauma and Falls in the Elderly, Sepsis and Infectious Emergencies in the Elderly, Evaluation of the Geriatric Patient with Chest Pain, Evaluation of Dyspnea in the Elderly, Abdominal Pain in the Geriatric Patient, Neurologic Emergencies in the Elderly, Evaluation of Syncope, Altered Mental Status and Delirium, and more!

Alcohol abuse remains a significant problem world-wide. The most commonly affected organ remains the liver with a risk of alcoholic liver disease (ALD) which can range from asymptomatic to alcoholic hepatitis to alcoholic cirrhosis. In 2010, alcohol-attributable cirrhosis was responsible for 0.9% of all global deaths. Given the sheer magnitude of alcohol abuse and alcoholic liver disease, an update on this topic is pertinent and relevant. This issue will focus on a variety of topics including alcoholism, the pathogenesis of ALD, the spectrum of ALD, the pathology of ALD, and the long-term management of patients with ALD. Alcoholic hepatitis is a particular type of ALD with a high mortality. This issue will explore the syndrome of alcoholic hepatitis, its prognostic markers, and the available therapies. Because alcohol intake can influence so many other conditions of the liver (especially hepatitis C), articles in this issue will also explore the impact of alcohol abuse on other liver conditions. In addition, several other topics such as nutritional therapy for ALD, ALD and liver cancer, and ALD and infection risk will be explored. Also, even though it is quite controversial, we will also explore liver transplant as a therapy for alcoholic liver disease including alcoholic hepatitis.

Drs. Robert Kotloff and Francis McCormack have assembled an expert team of authors on the topic of Rare and Orphan Lung Diseases. Articles include: Lymphangioleiomyomatosis, Pulmonary Lymphangiomatosis, Langerhans Cell Histiocytosis and other Histiocytic Diseases of the Lung, Pulmonary Alveolar Proteinosis, Pulmonary Alveolar Microlithiasis, Primary Ciliary Dyskinesia, Birt-Hogg-Dube Syndrome, Hermansky-Pudlak Syndrome, Hereditary Hemorrhagic Telangiectasia, Non-CF Bronchiectasis, Eosinophilic Lung Diseases, Benign Metastasizing Leiomyomata, and more!