Bøger i Pharmaceutical Science, Volume 2 serien
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1.074,95 kr. This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, andmetabolism and elimination half-life, drug¿drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied inpharmacokinetic, metabolomic, and bioanalytical studies.Key Features:¿ Presents pharmacokinetic and biotransformation parameters used for pre-clinical safetyevaluations¿ Depicts experimental and biophysical techniques used in bioanalytical and metabolomicstudies¿ Summarizes in silico, in vitro, and in vivo methods used in drug¿enzyme interactions, drug¿drug interactions, and toxicokineticsWritten by a global team of experts, this book is a valuable resource for drug discovery scientists,drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedicalscientists, healthcare professionals, researchers, teaching faculty, and students.
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- 1.074,95 kr.