Bøger udgivet af International Agency for Research on Cancer

This is the first and only handbook to provide a comprehensive review of the critical intermediates in the first step of the process of carcinogenesis. This volume reviews current knowledge of DNA adducts formed by a wide range of classes of chemical compound, including the metabolism of chemicals, mechanisms of adduction, preparation and properties of standard compounds, adduct formation in vitro, measurements of adducts in humans, and biological significance. Additional chapters review our understanding of specific types of gene damage and mutagenecity and their reaction to cancer. This volume will provide invaluable, up-to-date facts for all researchers in mechanism of carcinogenesis, toxicology, and molecular epidemiology.

Since the beginning of this century, "clusters" of certain forms of cancer--particularly leukemia in children and Hodgkin's disease--have been reported around locations of specific environmental hazards. Identification of such clusters is not an easy task, since there is no exact definition of what a cluster is. This monograph describes the variety of statististical techniques cuurently in use, and their application to simulated data-sets chosen to represent a range of clustering scenarios. The scientists who developed these techniques were invited to apply their methodology to these data-sets and to share their conclusions in this volume. In addition, these researchers describe in complete detail how they proceeded with the analysis, since an element of subjectivity figures prominently in the application and interpretation of some of these methods. The identification and analysis of disease clusters can yield significant clues in epidemiologic research, and as such will continue to be an important subject of cancer research and epidemiology for the foreseeable future.

This volume assesses formal methods for the quantitative estimation and prediction of human cancer risks. Quantitative estimates of cancer risk can be expressed in different ways. In some cases estimates of risk under conditions prevailing in the origina