Bøger udgivet af Humana Press Inc.

This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder (ADHD). Twenty-nine comprehensive chapters are divided into three distinct sections: clinical aspects, pathophysiological aspects, and therapeutic aspects. Together, these chapters present the environmental, genetic and neurodevelopmental factors in the generation of oxidative stress in psychiatric disorders, with particular emphasis on the biochemical changes associated with oxidative stress in dopaminergic and glutamate neurotransmission as well as mitochondrial dysfunction in the brain and peripheral cells. Through an investigation of glutamic acid decarboxylase (GAD) abnormalities in schizophrenia, the book provides a coherent framework to account for the impact of oxidative stress on pathological phenomena ranging from cellular to cognitive and clinical aspects. It describes biomarkers of oxidative damage, the role of oxidative stress in numerous abnormalities of biochemical pathways in the pathophysiology of schizophrenia, the development of new investigative techniques, specially neuroimaging, and studies of apoptotic pathways that seem to prove neurodegenerative and neurodevelopmental theories.Written by leading researchers in their fields, Studies on Psychiatric Disorders explores therapeutic approaches with aspects of various antioxidants, cryostimulation, and hyperbaric oxygen treatment in oxidative stress in neuropsychiatric diseases. The volume also discusses the role of antipsychotics in the treatment of schizophrenia on nitric oxide generation and biomarkers of oxidative stress together with the clinical symptomatology. Overall, it proposes that novel therapeutic strategies such as supplementation with antioxidants¿in particular polyphenols, ¿-3 fatty acids orcombination of both¿could be effective for long-term treatment of some neuropsychiatric disorders.

This book provides current glycoinformatics methods and protocols used to support the determination of carbohydrate structures in biological samples as well as carbohydrate structure databases, the interaction of carbohydrates with proteins, and theoretical and experimental methods to study their three-dimensional structure and dynamics.

This volume discusses various basic and advanced methods and protocols that have been proven to be successful among certain bacterial species, or a family of species, in type III secretion systems (T3S system).

This volume provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, and methods for the analysis and detection of microbial adaptation strategies.

Part I covers monoclonal antibody generation, Part II deals with monoclonal antibody expression and purification, Part III presents methods for monoclonal antibody characterization and modification, and Part IV describes selected applications of monoclonal antibodies.

As part of the Current Clinical Oncology series, Lymphoma: Diagnosis and Treatment will be of value to medical oncologists, hematologists, radiation oncologists, and all physicians involved in the care of patients with lymphoid malignancies.

Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book.

Skeletal Development and Repair: Methods and Protocols is a compilation of a variety of skeletal research protocols utilizing the laboratory mouse as the platform for surgical manipulation and/or transplantation as well as the source of tissues and cells for in vitro culture and analyses.

In this book, experts present a broad range of available and developing techniques for the analysis of gene expression at the DNA, RNA, and protein levels. A collection of clearly described and illustrated chapters includes tips and implementation advice.

This volume systematically reviews the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as "oxidative stress," in the pathology of Alzheimer's disease.

Nanotechnology is exposing the properties of DNA in unprecedented detail leading to new insights on the behavior and function of DNA. This book is a guide to scientists of all backgrounds and aims to ignite interest and activity in this young research field.

The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. The volume is divided in four sections: the first two deal with basic adipose tissue and adipokine biology, while the last two address the problem of obesity and alterations in adipose tissue function from an epidemiological and clinical standpoint.

Here is a concise review of urgent and emergent urological conditions, covering diagnostic and therapeutic considerations in traumatic, infectious, obstructive, hemorrhagic, iatrogenic, vascular and congenital urological emergencies in adults and children.

This fully updated second edition covers disease management and prevention, explores up-to-date information on demographic trends, and includes a host of useful case studies. A standalone section explains how to conduct a comprehensive nutritional assessment.

Studies on Diabetes examines how increased oxidative and nitrosative stress - one of the leading causes of diabetes complications - pathologically affects multiple tissues in the body. Each chapter provides the reader with invaluable insight to the complicated mechanisms responsible for diabetes complications and vascular disease.

In Osteoporosis and Osteoarthritis expert investigators detail modern tools to enhance discovery in bone and cartilage biology and promote translational research in osteoporosis and osteoarthritis.

Herpes Simplex Virus: Methods and Protocols provides a wide collection of protocols employed in various levels of herpes virus research, including basic protocols on growing viruses in cell culture and cloning, manipulating and preparing viral DNA.