Bøger udgivet af Elsevier Science

The Cardiac Conduction System: Evolution, Development, and Therapeutic Potential, the latest release in the Hot Topics in Physiology series, provides the reader a thorough and comprehensive review of this intricate system. The book covers conventional topics: anatomy, electrophysiology, and key cellular characteristics, as well as emerging topics: patient specific computer modelling, induced pluripotent stem cells, and in vivo editing as state-of-the-art treatment strategy. Given the exhaustive coverage of topics, this book is "go-to reference" for the cardiac conduction system for years to come. This volume was published in association with the International Union of Physiological Sciences (IUPS). It is an ideal reference for academics and researchers in anatomy, physiology, cardiology, electrophysiology, biomedical engineering and medical education at Undergrad, Masters, PhD, and Post-Doc levels.

Targeted Therapy for Central Nervous System: Formulation, Clinical Challenges and Regulatory Strategies presents research on various delivery methods of drugs to the central nervous system and brain. This volume examines targeted therapies for neurodegenerative disorders and succinctly outlines the future of drug delivery systems, highlighting significant advancements specifically relating to central nervous system delivery. This book will be of great interest to researchers working in the field of neuroscience and pharmacology as well as clinicians (pharmacists, radiologists, psychiatrists).

Handbook of Neurodegenerative Disorders: Mechanism, Diagnostic and Therapeutic Advances provides a comprehensive review on the current biomedical studies aimed at identifying the underlying causes of neurodegeneration. This book reviews the most recent developments in molecular and cellular processes altered during neurodegeneration. Divided into four parts, the first covers the mechanism of cell death in neurodegeneration. The second section reviews the recent progress in gene and gene products in neurodegeneration, including Huntington's disease, Parkinson's disease, Friedreich' s ataxia, and spinal muscular atrophy. The final sections cover the current and future diagnostic techniques of neurodegenerative disorders along with therapeutic approaches.

From Anatomy to Function of the Central Nervous System: Clinical and Neurosurgical Applications features neuroradiologic images that represent today, one of the most effective resources able to detect the anatomy of the nerve structures. Simultaneously featuring neuroimages, readers can study the functional aspects of the entire central nervous system with detailed captions that describe in detail how to use and interpret them. This book includes images of the brain dissected with the Klingler’s method and white matter fiber dissection. By integrating the anatomo-functional description with the synaptic organization of the CNS, this reference is useful for anyone who wants to understand how the activity of a nerve structure arises, describing its microstructure, neurotransmitter phenotype, and neural activity. It also features descriptions of pathologic conditions which result from neuroanatomical and/or neurofunctional alterations and includes neurosurgical aspects.

Biofuels and Sustainability: Life-cycle Assessments, System Biology, Policies, and Emerging Technologies presents the current progress and challenges related to the sustainability of biofuels. Addressing a wide range of issues, the book examines the methods and technologies, policies for sustainable biofuels, impacts of advanced fuels, recent advances, and future research prospects. Reflecting new developments, emphasis is given to new biological/biochemical approaches that offer the most efficient, cost-effective, and sustainable strategies for biofuel production. Divided into five parts, the first provides an overview of biofuels, the need for alternate fuels, carbon footprints, life cycle assessments, environmental aspects, various generations of biofuels, biofuel production from lignocellulosic material, and artificial intelligence in biofuel production. Part 2 examines the various methods and technologies for biofuels production, with case studies from the USA, UK, and Brazil. Part 3 explores the policies for sustainable biofuels, including current standards, with applications from the USA, European Union, Asia, and Africa. Part 4 analyses the impacts of advanced fuels in the decarbonization of transport, climate change mitigation, sustainable agriculture, and water resources, with perspectives from developed and developing countries. Finally, Part 5 critically reviews the recent advances and future research prospects related to termites, insects, metabolic engineering, microorganisms, and bioreactors.

Biofuels and Bioproducts from Lignocellulosic Materials: Biomaterials is Volume 3 of a comprehensive three-volume set that explores the various possibilities of adding value to lignocellulosic biomass materials by transforming them into bioproducts, biofuels and biomaterials. With an emphasis on microbial biotechnological solutions, each volume examines the use of renewable natural resources, agriculture waste management, and valorization of agro-wastes to sustainably produce energy and fuels, nutraceuticals and pharmaceuticals, chemicals, and biomaterials. Volume 3 addresses all aspects of biomaterials production from lignocellulosic materials. The book examines recent innovative approaches for conversion and assesses the role of engineered microorganisms and their mechanisms of action for biomaterials production. The opening chapter of the book reviews the properties, types, production, and applications of various biomaterials. Following this, readers will find critical reviews of the latest developments and step-by-step guidance on key processes and methods, including novel, eco-friendly methods for biomass conversion that reduce waste. Finally, dedicated chapters review the techno-economic and LCA of lignocellulosic biomass conversion into different biomaterials such as bio-adhesives, biopolymers, bio-packaging materials, bioplastics, and value-added functional biomaterials. Biofuels and Bioproducts from Lignocellulosic Materials: Volume 3: Biomaterials is a valuable reference for students, researchers, and professionals involved in processing lignocellulosic materials for the production of bioenergy, biomaterials, and bioproducts.

Aircraft Financing and Leasing: Tools for Success in Aircraft Acquisition and Management, Second Edition provides students and industry professionals with unique insights into the latest developments in the Commercial Aircraft and Engine Leasing and Financing industry that has grown into one of the most distinctive and important industries globally. This book offers a blend of academic and professional views that make it educational and relevant to the everyday operations of the industry. It can be used as a stand-alone textbook as well as a practitioner's guide. Given the impact of the COVID-19 virus on airlines around the world, the industry has experienced substantial changes since the first edition was published. This second edition is thoroughly revised and includes some new case studies and an entirely new chapter on Environmental Considerations with Respect to Aviation Finance. Aircraft Financing and Leasing details the industry¿s foundational concepts, including aviation law and regulation, airline credit analysis, maintenance reserve development, insurance, transaction cost modeling, risk management tools such as asset and credit diversification, and the art of lease negotiations. Different types of aircraft are explored, highlighting their purposes, as well as when and why airline operators and investors choose specific models over others. In addition, the book covers important factors such as modeling financial returns for leased aircraft and appraising aircraft values. Users will find this an ideal resource for practitioners or as an outstanding reference for senior undergraduate and graduate students.

Advanced Transport Biofuels: Production, Economics, and Sustainability provides a comprehensive review of the latest in the global production, economics, and sustainability of advanced transport biofuels. Drawing upon the latest developments in academia and industry globally, the book reviews biofuels policy and the technoeconomics of biofuels production. The technical considerations in the combustion of biofuels are discussed alongside the latest lab-scale and industrial-level combustion property testing using biofuels and biojet fuels. Finally, a lifecycle analysis of biofuel production is conducted related to the sustainability issues in production. This is an invaluable review of the current state of the biofuels industry, policies, technologies, and economic and sustainability issues related to biofuels applications that will be of interest to graduate students and researchers involved in the development and implementation of alternative fuels in the transportation industry. The book will also be of interest to professional engineers and policymakers working in the automotive industry and involved in the application of alternative fuels.

Hydrogen Production, Transportation, Storage, and Utilization: Theoretical and Practical Aspects is a comprehensive introduction to the theoretical and practical aspects of hydrogen as an energy vector. The book walks the reader through the upstream, midstream, and downstream at each stage, explaining concepts, methods, applications, and economics to provide a broad understanding of hydrogen energy. It explains each of the key aspects of hydrogen energy in dedicated chapters, guiding readers through the fundamentals of hydrogen as an energy vector to economic, safety, and environmental considerations. Chapters analyze the methods for hydrogen production and provide a review of the fundamental, technological, and environmental aspects of these methods while also examining physical, chemical, and material methods for hydrogen storage and explaining the corresponding, underlying theory and concepts. Other sections explore the downstream aspects of hydrogen in transportation, power generation, energy supply in industry, and as a feedstock in refineries and the chemical industry.

Medical Nanobiotechnology: Nanomedicine for Repair, Regeneration, Remodelling, and Recovery thoroughly reviews the potential of functionalized biomaterials as ideal candidates for nanomedicine. The book covers advances in the development of nanotheranostic agents that can simultaneously help in both effective therapy and rapid diagnosis. A range of materials is covered, including their fabrication, characterization and assessment, as well as their functionalization and incorporation into implants and medical devices. Clinical aspects and challenges are discussed, helping bridge the gap between laboratory research and the translational impact as nanomedicine begins to develop point-of-care customized therapy. This book is an interdisciplinary reference for researchers and R&D groups interested in the development of novel nanobiomaterials for therapeutic applications.

Environmental Materials and Waste: Circular Economy and Pollution Abatement, Second Edition, contains the latest information on environmental sustainability as a wide variety of natural resources are increasingly being exploited to meet the demands of a worldwide growing population and economy. The book takes a multidisciplinary approach to fully realize the number of by-products which can be remanufactured, providing the foundation needed across disciplines to tackle this issue. As awareness and opportunities to recover valuable resources from process and bleed streams is gaining interest, sustainable recovery of environmental materials, including wastewater, offers tremendous opportunity to combine profitable and sustainable production. In this 2nd edition, operational principles of circular economy for sustainable development with reference to environmental waste shall be covered. Circular economy research is discussed in depth as it has gained considerable momentum in the scientific literature thus far, and both conceptual debates and the creation of useful implementation strategies are still in their infancy. Although circular systems are now being implemented, this book will emphasize the importance to properly consider and convert circular economy goals and principles into actions. As a whole, this 2nd edition of Environmental Materials and Waste covers a wide range of issues that must be covered in order to improve environmental sustainability.

Microbial Diversity in the Genomic Era: Functional Diversity and Community Analysis, Second Edition presents techniques used for microbial taxonomy and phylogeny, along with their applications and respective strengths and challenges. The book incorporates recently developed biosystematics methods and approaches to assess microbial taxonomy, with suitable recommendations for where to apply them across the range of bacterial identification and infectious disease research. Sections provide a broad overview of microbial genomics research and microbiome directed medicine and update on molecular tools for microbial diversity research, extremophilic microbial diversity, functional microbial diversity across application areas, microbial diversity and infectious disease research, and future directions. Step-by-step methodologies are provided for key techniques, along with applied case studies that break down recent research studies into practical components, thus illuminating pathways for new studies across the field.

Railway Noise and Vibration: Mechanisms, Modelling, and Means of Control, 2nd Edition provides a complete overview of the state of the art in rail noise and vibration theory and modelling. This book describes each source of noise and vibration, such as rolling noise, curve squeal, bridge noise, aerodynamic noise, ground vibration and ground-borne noise, and vehicle interior noise in a systematic way, covering relevant theoretical modelling approaches and their practical implementation, with extensive examples of noise control technology applied at source. Noise and vibration are key obstacles to further development of railway networks worldwide for high-speed intercity traffic, freight and suburban metros and light-rail systems. With noise problems all too often dealt with inefficiently due to a lack of understanding of the problem, this new edition is an invaluable reference for all those working with noise and vibration from railways, whether in industry, consultancy, or academic research.

Quantum computing offers great promise in a wide variety of applications that need computational power beyond the limits of current conventional computers, including machine learning and AI, cryptanalysis, and simulation of quantum physics and chemistry. Fundamentally new programming technologies are required to develop quantum software that can realize the super-power of quantum computing. Foundations of Quantum Programming, Second Edition provides a systematic exposition of the subject of quantum programming. The emphasis is placed on the foundational concepts, methods and techniques that can be widely used for various quantum programming models and languages. It describes how programming methodologies developed for current computers can be extended for quantum computers, along with new programming methodologies that can effectively exploit the unique power of quantum computing. It introduces a chain of quantum programming models from sequential to parallel and distributed programming in the paradigm of superposition-of-data to the paradigm of superposition-of-programs. It also presents a series of logical and mathematical tools for verification and analysis of quantum programs, including invariant generation, termination analysis and abstract interpretation.

Recent Trends in Cold-Formed Steel Construction, Second Edition focuses on the application and use of this important construction material. In this updated edition, new chapters take on these developments, offering updates on cutting-edge new technologies and design methods for using cold-formed steel as a structural material and providing technical guidance on how to design and build sustainable and energy-efficient cold-formed steel buildings. Sections introduce codes, specifications and design methods, provide computational analysis of cold-formed steel structures, examine the structural performance of cold-formed steel buildings, and review thermal performance, acoustic performance, fire protection, floor vibrations and blast resistance. Over the last few years, there has been major breakthroughs for cold-formed steel design with modular building applications now becoming more widely accepted. Other scientific developments include research on system reliability applications, AI machine learning, and the use of high strength steel, as well as new connection methods and changes in DSM codes.

In the last two decades, the field of time-frequency analysis has evolved into a widely recognized and applied discipline of signal processing. Besides linear time-frequency representations such as the short-time Fourier transform, the Gabor transform, and the wavelet transform, an important contribution to this development has undoubtedly been the Wigner distribution (WD) which holds an exceptional position within the field of bilinear/quadratic time-frequency representations.The WD was first defined in quantum mechanics as early as 1932 by the later Nobel laureate E. Wigner. In 1948, J. Ville introduced this concept in signal analysis. Based on investigations of its mathematical structure and properties by N.G. de Bruijn in 1967, the WD was brought to the attention of a larger signal processing community in 1980. The WD was soon recognized to be important for two reasons: firstly, it provides a powerful theoretical basis for quadratic time-frequency analysis; secondly, its discrete-time form (supplemented by suitable windowing and smoothing) is an eminently practical signal analysis tool.The seven chapters of this book cover a wide range of different aspects of the WD and other linear time-frequency distributions: properties such as positivity, spread, and interference term geometry; signal synthesis methods and their application to signal design, time-frequency filtering, and signal separation; WD based analysis of nonstationary random processes; singular value decompositions and their application to WD based detection and classification; and optical applications of the WD. The size of the chapters has been chosen such that an in-depth treatment of the various topics is achieved.

Previous ed. published: Amsterdam; Boston: Elsevier, 2002, under title: Modelling in transport phenomena.

API Design for C++, Second Edition?provides a comprehensive discussion of Application Programming Interface (API) development, from initial design through implementation, testing, documentation, release, versioning, maintenance, and deprecation. It is the only book that teaches the strategies of C++ API development, including interface design, versioning, scripting, and plug-in extensibility. Drawing from the author's experience on large scale, collaborative software projects, the text offers practical techniques of API design that produce robust code for the long-term. It presents patterns and practices that provide real value to individual developers as well as organizations. The Second Edition includes all new material fully updated for the latest versions of C++, including a new chapter on concurrency and multithreading, as well as a new chapter discussing how Objective C++ and C++ code can co-exist and how a C++ API can be accessed from Swift programs. In addition, it explores often overlooked issues, both technical and non-technical, contributing to successful design decisions that produce high quality, robust, and long-lived APIs. It focuses on various API styles and patterns that will allow you to produce elegant and durable libraries. A discussion on testing strategies concentrates on automated API testing techniques rather than attempting to include end-user application testing techniques such as GUI testing, system testing, or manual testing. Each concept is illustrated with extensive C++ code examples. Fully functional examples and working source code for experimentation are available online.

Advances in Pig Welfare, Second Edition continues its complete coverage of the field with fully updated information and analysis of current issues in the key areas of pig welfare. It is a comprehensive review covering both recent developments and persistent welfare issues. The book has been expanded with 10 new chapters addressing the most relevant and significant issues in industry with a more global perspective. The book is divided into four sections, starting with an introduction (Part 1) to major topics in pig welfare, such as pigs¿ needs, including affective states and positive animal welfare. Part two provides an overview of production systems and reviews welfare hotspots and mitigation. Part three covers pig welfare management topics, such as pig-human interactions and precision livestock farming. Global perspectives on pig welfare, including economics, legislation, farmers attitudes and climate change, are covered in Part 4. Written by an international team of renowned researchers in the field, the book continues to be a useful resource for practicing vets involved in welfare assessment, welfare research scientists and students, and indeed, anyone with a professional interest in the welfare of pigs.

Organic Farming: Global Perspectives and Methods, Second Edition provides the core definition and concepts of organic farming, also addressing current challenges and goals. The book provides a comprehensive resource, from sustainability to influences on the ecosystem, including the significance of seed, soil, water and weed management, and other important aspects. In addition, it presents advancements in the field and insights on the future. This fully revised and updated edition expands coverage to include important economic considerations, understanding the influence of nanotechnology on organic farming, vertical farming, organic farming and livestock management, as well as the future of organic farming. Written by a team of global experts to provide current concepts of organic farming, this resource is valuable for researchers, graduate students, and post-doctoral fellows from academia and research institutions.

Applied Plastics Engineering Handbook: Processing, Sustainability, Materials, and Applications, Third Edition presents the fundamentals of plastics engineering, helping bring readers up-to-speed on new plastics, materials, processing and technology. This revised and expanded edition includes the latest developments in plastics, including areas such as biodegradable and biobased plastics, plastic waste, smart polymers, and 3D printing. Sections cover traditional plastics, elastomeric materials, bio-based materials, additives, colorants, fillers and plastics processing, including various key technologies, plastic recycling and waste. The final part of the book examines design and applications, with substantial updates made to reflect advancements in technology, regulations, and commercialization. Throughout the handbook, the focus is on engineering aspects of producing and using plastics. Properties of plastics are explained, along with techniques for testing, measuring, enhancing, and analyzing them. Practical introductions to both core topics and new developments make this work equally valuable for newly qualified plastics engineers seeking the practical rules-of-thumb they don't teach you in school and experienced practitioners evaluating new technologies or getting up-to-speed in a new field.

Functional Fillers: Chemical Composition, Morphology, Performance, Applications, Second Edition covers the structure, physical properties, electrical and magnetic properties, and applications of fillers. The book includes two sections, with the first part covering classic fillers, analyzing the current modifications in relation to composition and morphology, and enabling enhancements in properties and applications. The second part presents the new generation of fillers, which provide designers with exceptional properties not previously available. Applications discussed include lubricants, anti-corrosion, antimicrobial, and more. Renewable fillers and recycling of fillers are covered as well.

Databook of Plasticizers, Third Edition contains data on more than 300 of the most important generic and commercial plasticizers in use today. The data comes from a range of sources beyond plasticizers manufacturers, allowing for a detailed comparison of properties of different plasticizers. Over 100 different data fields are provided, from general information, such as molecular structure and formula, to physical properties, health and safety information, ecological properties, and recommendations regarding appropriate use and performance of each plasticizer. This data book is an essential resource for engineers, technicians and materials scientists responsible for specifying a plasticizer. The book has been updated to reflect the recent changes in plasticizer approvals for production of various materials, including chloroparaffins, refined oil derivatives, and phalates, and also includes data details on a range of new plasticizers that have recently gained market approval. It serves as an ideal companion to the Handbook of Plasticizers.

Molten Salt Reactors and Thorium Energy, Second Edition is a fully updated comprehensive reference on the latest advances in MSR research and technology. Building on the successful first edition, Tom Dolan and the team of experts have fully updated the content to reflect the impressive advances from the last 5 years, ensuring this book continues to be the go-to reference on the topic. This new edition covers progress made in MSR design, details innovative experiments, and includes molten salt data, corrosion studies and deployment plans. The successful case studies section of the first edition have been removed, expanded, and fully updated, and are now published in a companion title called Global Case Studies on Molten Salt Reactors. Readers will gain a deep understanding of the advantages and challenges of MSR development and thorium fuel use, as well as step-by-step guidance on the latest in MSR reactor design. Each chapter provides a clear introduction, covers technical issues and includes examples and conclusions, while promoting the sustainability benefits throughout.

Solvents are used in nearly all industries, from cosmetics to semiconductors, and from biotechnology research to iron and steel production. This book is a comprehensive and extensive textual analysis of the principles of solvent selection and use. It is a balanced presentation of solvent performance, processing characteristics, and environment and health issues. The book is intended to help formulators select ideal solvents, safety coordinators to protect workers, legislators and inspectors to define and implement technically correct public safeguards on solvent use, handling, and disposal. The volume begins with discussion of solvent use in over 30 industries, which are the main consumers of solvents. The analysis is conducted based on available data and contains information on the types (and frequently amounts) of solvents used and potential problems and solutions. This followed by discussion of residual solvents left in final products. The environmental impact of solvents, such as their fate and movement in water, soil and air, fate-based management of solvent containing wastes, and ecotoxicological effects are discussed. Practical guidance is also provided on immediate reaction to human solvent poisoning, persistence of symptoms of solvent exposure, and effects of solvents on various parts of the human body. These expert contributions should be frequently consulted by solvent users and agencies which are responsible for protection of people in industrial environments. Possibilities for solvent substitution are also discussed, with emphasis on supercritical solvents, ionic liquids, ionic melts, and agriculture-based products. Solvent recycling, removal from contaminated air, and degradation are covered.

Measuring and Managing Information Risk: A FAIR Approach, Second Edition provides a proven and credible framework for understanding, measuring, and analyzing information risk of any size or complexity using the Factor Analysis of Information Risk (FAIR) methodology developed over ten years and adopted by corporations worldwide. This new edition covers such key areas as risk theory, risk calculation, scenario modeling, and communicating risk within the organization, and also includes new chapters and essays from industry professionals. It provides a step-by-step guide to help managers make better business decisions by understanding their organizational risk. The field has advanced significantly in the past 10 years and this all-new edition reiterates the importance of the foundations of risk measurement but adds information about modern methods to integrate quantitative risk assessment methods into your security programs. This includes the integration of security telemetry data, outside data sources, approaches to automating FAIR assessments, and how to align methods and programs to security standards and regulations. Further discussed is how such approaches are being used by third-party agencies to provide CRQ data to the investors, underwriters, and regulators. This book is a valuable resource for all those who need the foundations, methods, and techniques for measuring, assessing, and communicating cyber risk to enable an organization to build an organizational IT risk management program. It serves as both a practical how-to guide for those new to the industry as well as tenured professionals that need a formalized guide for implementation.

Pharmacoepigenetics, Second Edition, Volume Ten in the Translational Epigenetics series, is a comprehensive reference on the role of epigenetics and epigenomics in drug discovery and development. Here, leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine.This new edition has been fully revised to address recent advances in epigenetics, from new natural and synthetic compounds with epigenetic effects to the role of epigenetics in the pathogenesis of a growing number of complex diseases, including further cancers, cardiovascular disorders, and brain disorders. Newly identified molecular components in the functional architecture of the epigenetic machinery, as well as practical and relevant pharmacoepigenetics topics related to COVID-19 and other world health challenges are also discussed.

Sample Handling and Trace Analysis of Pollutants: Innovations to Determine Organic Contaminants, Second Edition reviews the latest technologies and challenges in trace analysis of environmental pollutants, from selecting the right approach to tips for performing analytic procedures and measuring and reporting results. Written by internationally renowned experts in environmental analysis from 5 continents and edited by leaders in the field, this completely updated and revised volume presents the latest techniques developed over the past 10 years, such as high-resolution mass spectrometry, biosensors and imaging techniques. Important tools for problem-solving in the determination of environmental pollutants are also discussed.Chapters cover emerging pollutants in the environment, such as nanomaterials, microplastics, metabolites and/or transformation products and antimicrobial resistances. Specific sections describe field sampling techniques and sample preparation in environmental matrices: air, water, soil, sediment and biota, focus on passive samplers, cover the determination of these environmental contaminants based on analytical techniques, such as the use of gas chromatography and liquid chromatography coupled to mass spectrometry, immunoassays, and biosensors as well as advanced analytical methods such as imaging techniques.