Bøger udgivet af Cold Spring Harbor Laboratory Press,U.S.

"Nobelist James D. Watson delves into his family history, exploring his ancestors' roots in Springfield, Illinois, and Chicago, and then focuses on his father James D. Watson, Sr., and his influence on Dr. Watsonp1ss success as an eminent scientist and as a writer. Contiguous people, such as Abraham Lincoln and Orson Welles, and events, such as the

Retinal disorders are a leading cause of blindness. This book examines the molecular basis of these diseases, focusing on genetic approaches that are improving both our understanding of the disease process and their diagnosis, as well as advances in gene therapy that have been used to cure patients and provide a model for treatment of other conditions.

The innate immune system is the first line of defense against infection. It is a generic rather than pathogen-specific response that recruits immune cells to sites of infection, promotes inflammation, and activates the adaptive immune system. This book examines the cell types that make up the innate immune system, the chemical signals they use to communicate, and the mechanisms that drive inflammation and other consequences of immune activation.

As universities increasingly spin off biotech companies and academics work more closely with these companies and the pharma industry, it is essential that they gain an understanding of intellectual property law and patenting. This book introduces the basic ideas and discusses how they apply to biomedical research and product development in the age of genomics.

Recent work has improved our understanding of the molecular and cellular bases of heart development and function. This book discusses these advances and the implications for diagnosis and treatment of heart disease, including stem cell therapy, tissue engineering, and transplantation.

Neuroscientists must now routinely use advanced molecular biology and tissue culture techniques in their research. This book provides a detailed practical guide to both fundamental and cutting-edge methods in these areas. Aimed specifically at neuroscientists, it includes protocols for working with DNA and RNA, cell purification and tissue culture, and microscopy, as well as numerous organism-specific techniques.

Neuroscientists must now routinely use advanced molecular biology and tissue culture techniques in their research. This book provides a detailed practical guide to both fundamental and cutting-edge methods in these areas. Aimed specifically at neuroscientists, it includes protocols for working with DNA and RNA, cell purification and tissue culture, and microscopy, as well as numerous organism-specific techniques.

This book provides a state-of-the-art view of human genetic variation and what we can infer from it, surveying: Â- How populations around the globe differ geneticallyÂ- 'Race' and biology Â- How genetic variation affects our healthÂ- The future of personalized medicine

Orphan is more than a book about disease and research--it gives voice to thousands of people who, all too often, have endured terrible illnesses, bravely faced arduous clinical trials, and, sometimes, have gained victories, almost always in silence. This book recounts extraordinary breakthroughs and hopes for the future. Many of the disorders that will end our lives are in some part genetically influenced. We really are all orphans, and this book is for all of us.

An essential guide for students in the life sciences, established researchers, and career counselors, this resource features discussions of job security, future trends, and potential career paths. Even those already working in the industry will find helpful information on how to take advantage of opportunities within their own companies and elsewhere.

Biology of Drosophila was first published by John Wiley and Sons in 1950. Until its appearance, no central, synthesized source of biological data on Drosophila melanogaster was available, despite the fly's importance to science for three decades. Ten years in the making, it was an immediate success and remained in print for two decades. However, original copies are now very hard to find. This facsimile edition makes available to the fly community once again its most enduring work of reference.

An up-to-date survey of the current exciting state of telomere biology. Telomeres--specialized structures found at the ends of chromosomes--are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

Hundreds of genomes have been completely sequenced in the past decade, significantly advancing our understanding of genome structure and function. Genomes comprises a collection of review articles reprinted from the 10th Anniversary issue of the journal Genome Research that capture the status of genomic research in a selection of model species--from microbes to human. Written by leaders in the field, each chapter focuses on a kingdom, group, or species and offers a unique perspective on the history, the current status, and future of genomics research. Topics addressed include gene regulatory networks in the fruit fly and the sea squirt, fungal genome evolution, mouse and rat mutagenesis, the future of crop plant genomics, how livestock genomics informs human medicine, the importance of the dog genome in studying human disease, and the search for "humanness" through human and chimp genome comparison. In addition, updates on emerging technologies in DNA sequencing and in gene prediction, as well as direction to relevant public resources, are given. This book serves as a valuable reference and teaching tool for established scientists in the genomics field and as a comprehensive overview for those with more general interests in biology.

In recent years, the eukaryotic microbe baker's yeast, Saccharomyces cerevisiae, has been used in many studies of cell biology common to multicellular organisms. This single-volume handbook explains metabolism as based on Saccharomyces.

George Beadle was a towering scientific figure whose work from the 1930s to 1960 marked the transition from classical genetics to the molecular era. Among other distinctions, he made the pivotal, Nobel Prize-winning discovery with Edward Tatum that the role of genes is to specify proteins. From 1946 to 1960 he led the Caltech Biology Division, rebuilding it to a powerhouse in molecular biology, and afterwards became a successful President of the University of Chicago. This is the first biography of a giant of genetics, written by two of the field's most distinguished contributors, Paul Berg and Maxine Singer.

This monograph, written by experts in the field, is devoted to the molecular analysis of addiction pathways in the brain. It provides an intensive overview of the fundamentals, state?of?the?art advances, and major gaps in the cell and molecular biology of drug addiction within the broader context of neuroscience. Addiction research is a branch of neuroscience and psychology. The emphasis in this book is on hard science and the market for it will be found among research investigators and grad students within the field of neuroscience. The research presented is not only applicable to the study of drug abuse and addiction, but has clear implications for clarifying mechanisms of learning and memory, neuroadaptation, perception, volitional behavior, motivation, reward, and other disciplines of neuroscience.

An up?to?date survey of the current exciting state of telomere biology. Telomeres?specialized structures found at the ends of chromosomes? are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

James Watson's fame as a scientist and research leader overshadows his considerable achievements as an innovator in the form and style of scientific communication. This book surveys Watson's books and essays from the perennially best-selling The Double Helix through his classic textbooks of the 1960s and 70s, polemics on ethical questions about genetic technology, to more recent works of autobiography.

Twenty-four true, wide-ranging tales of crime, history, human behavior, illness, and ethics, told from the personal perspective of the author, an eminent physician-lawyer who uses the stories to illustrate the principles of human genetics and to discuss the broader issues.

Contains reprints of 20 significant papers published by scientists while at Cold Spring Harbor, with a non-technical explanation of the work's significance at the time and a profile of the investigator concerned.

Lab Math: A Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at the Bench, 2nd edition, collects in one place the numbers and equations you rely on for your experiments and use to report your data-what they mean and how to use them-as well as easy-to-follow shortcuts for making the math easier.

Receptor tyrosine kinases are cell-surface receptors that respond to numerous hormones and growth factors, including insulin, insulin-like growth factors, epidermal growth factor, and nerve growth factor. They activate highly conserved intracellular signaling pathways that regulate cell proliferation, differentiation, and metabolism, playing essential roles in developing and adult animals. This book examines the nature of these receptors and their ligands, the molecular mechanisms that they regulate within cells, and the roles of the receptors in normal physiology and control of embryogenesis. It also discusses how dysfunction of these mechanisms can contribute to cancer and other diseases.