Bøger udgivet af Cold Spring Harbor Laboratory Press,U.S.

Color and learn! Welcome to your familyDLall the wonderful inhabitants of Planet Earth. We share something very special with every human being, animal, plant, and microscopic creature. What do we share with all living things? We are all GENE MACHINES! Discover all the books in the ENJOY YOUR CELLS series, each available in coloring book and full-color formats! Recommended for ages 7 and up.

Color and learn! Planet Earth can be a dangerous place for all living creatures, including you. You can usually escape from erupting volcanoes and floods. You can protect your body from the blazing Sun and freezing snow. But wherever you live and whatever the weather, you cannot escape GERMS! Discover all the books in the ENJOY YOUR CELLS series, each available in coloring book and full-color formats! Recommended for ages 7 and up.

Color and learn! Once upon a time you were very, very small. In fact, you were made of just one tiny cell. But the incredible thing about that tiny cell was that all the instructions to make you were hidden inside it. And all because of a very important chemical substance called DeoxyriboNucleic Acid--everyone calls it DNA. Discover all the books in the ENJOY YOUR CELLS series, each available in coloring book and full-color formats! Recommended for ages 7 and up.

We learn and form memories by making changes to neurons and neuronal circuits in the brain. This book examines the molecular and cellular bases for these processes, as well as how memories are stored, maintained and retrieved.

Epilepsy affects millions worldwide and represents a variety of disorders characterized by seizures. This book examines the neurobiological bases of these conditions and current research into treatment strategies.

This collection reviews our understanding of the molecular mechanisms involved in establishing and maintaining cell polarity, as well as their relevance for human disorders. Contributors discuss how cells coordinate signaling pathways, membrane trafficking, and cytoskeletal remodeling to ensure proper spatial arrangement of cellular components. Processes such as transcytosis, exocyst-mediated vesicle trafficking, and endosomal sorting are covered in detail. Throughout, the focus is on epithelial cells and how polarity mechanisms facilitate the development of their apical and basolateral surfaces, tube formation, exchange of waste and nutrients, and the generation and maintenance of specialized structures at the cell surface.

Cancer occurs because cells develop mutations that confer a growth advantage. Different subpopulations within the tumor can possess different mutations, and new mutations occur as the cancer progresses. This can allow the tumor to develop resistance to chemotherapy and is a major therapeutic challenge. This book examines this quasi-evolutionary process involved and how work in both molecular and computational biology is shedding light on it.

Cilia and flagella are protrusive structures on the surface of cells that perform a variety of functions. The beating of flagella and motile cilia, for example, can be used to propel cells or move material over their surface, and cilia play important roles in signaling between cells. This book examines the structure and function of cilia and flagella and their roles in cell motility, signaling and development.

Ion channels convey ions such as potassium, sodium and calcium across cellular membranes and play critical roles in normal physiology. This laboratory manual is based on the popular Cold Spring Harbor Laboratory course that has run for many years. It includes state-of-the-art techniques for analysis of ion channel activity and function.

Restriction enzymes cleave DNA at specific recognition sites and have many uses in molecular biology, genetics, and biotechnology. More than 4000 restriction enzymes are known today, of which more than 621 are commercially available, justifying their description by Nobel Prize winner Richard Roberts as "the workhorses of molecular biology." This book by Wil Loenen is the first full-length history of these invaluable tools, from their recognition in the 1950s to the flowering of their development in the 1970s and 1980s to their ubiquitous availability today. She is the author of several authoritative and widely appreciated reviews of the enzymes' biology.

The 80th Cold Spring Harbor Symposium was held to mark the 150th anniversary of Gregor Mendel's landmark 1865 presentation of his paper "Experiments on Plant Hybridization", which laid the groundwork for modern genetics. The Symposium Proceedings addresses 21st Century Genetics: Genes at Work, and provides a current synthesis of genetic mechanisms and genome/chromosome biology. This volume spans a broad range of topics that reflect our current understanding of genetic mechanisms in humans and other organisms. Themes include chromosome biology and nuclear structure, topologically associating domains, gene-enhancer interactions, chromatin and epigenetics, gene regulation and control, developmental regulation, RNA controlling elements, maintenance of genome stability, nuclear receptors, circadian clocks and aging, and genome editing. The Conversations included in this volume are based on interviews conducted during the Symposium and offer a broader anecdotal perspective on this fascinating subject by many of the world's leading investigators.

The machinery that controls how DNA is packaged and genes are activated plays an important role in cancer. This book examines the functions of components of this machinery, how they can be dysregulated, and the prospects for targeting them therapeutically.

CRISPR-Cas-based techniques are revolutionizing molecular biology and genetics. The technology is based on a bacterial immune system that uses specific guide RNAs to target foreign DNA sequences for degradation. It has been adapted for genetic engineering and has a wide variety of applications in all fields of biology and the development of new therapeutic approaches.

Genetics is the science of biological inference from regularities in patterns of inheritance. It is a fundamentally analytical enterprise. It has become clear, especially in the last 50 years, that many important things about biology can be learned using genetic analysis that cannot be learned any other way. Genetic analysis is the best window we have into the workings of evolution. This book is organized around the specialized words that capture the most fundamental genetic abstractions. It conveys the meaning and utility of the essential and helpful ones as they are used today.

Epilepsy affects millions worldwide and represents a variety of disorders characterized by seizures. This book examines the neurobiological bases of these conditions and current research into treatment strategies.

Mitosis - division of a cell to produce two daughter cells - is a complicated process that must be highly coordinated to ensure events such as chromosome separation take place at the right time and in the right order. This book provides a state-of-the-art examination of the mechanics of mitosis, how the process is regulated, and the different checkpoints and quality-control steps involved.

Using R at the Bench: Step-by-Step Data Analytics for Biologists is a convenient bench-side handbook for biologists, designed as a handy reference guide for elementary and intermediate statistical analyses using the free/public software package known as "R." This handbook for working scientists provides a simple refresher for those who have forgotten what they once knew and an overview for those wishing to use more quantitative reasoning in their research. Statistical methods, as well as guidelines for the interpretation of results, are explained using simple examples. Throughout the book, examples are accompanied by detailed R commands for easy reference.

This book is a highly illustrated sketch of the history of the Lab's research and educational activities from rustic beginnings to world renown. It will contain an introduction by Bruce Stillman, and a main text by Jan Witkowski consisting of three elements: an illustrated essay about the research done at the Lab's founding institutions from 1890 through 1962; a second illustrated essay about the research discoveries and accomplishments in education from 1962 to the present day; a section of "vignettes," short, highly structured accounts of 40 highlights from the Lab's track record of research.

We learn and form memories by making changes to neurons and neuronal circuits in the brain. This book examines the molecular and cellular bases for these processes, as well as how memories are stored, maintained and retrieved.

The generation of new neurons is a complex process that represents an extreme example of neuroplasticity. It may play a part in memory and brain repair and is implicated in various neurological conditions. This book discusses current approaches used to investigate neurogenesis, our understanding of the molecular mechanisms involved, and the roles of neurogenesis in diseases such as epilepsy and various psychiatric disorders.

Hepatitis B affects hundreds of millions of individuals worldwide and is a leading cause of liver cancer. This book examines our understanding of the biology of the Hepatitis B virus that causes the disease, the immune responses it elicits, and its role in liver cancer. It also discusses the related Hepatitis Delta virus and its effects.

"A subject collection from Cold Spring Harbor Perspectives in Biology."

Metabolic pathways used to be 'road maps' most biologists learnt as undergraduates and then promptly forgot. Recent work has revealed how changes in metabolism are closely linked to many aspects of cell behavior and the development of cancer and other diseases. This book represents both a new look at metabolism and a refresher course. It surveys the major metabolic pathways, places these in biological context, and highlights the key control points that control cell behavior and can become dysregulated in disease.

Fungal infections affect millions of individuals worldwide. They a particular danger to immunocompromised individuals, such as those with HIV/AIDS, and invasive infections often have a mortality rate greater than 50%. This book examines our understanding of the biology of the major fungal pathogens, together with the host response, epidemiology of fungal diseases and current treatment strategies.

Experimental Design for Biologists is a unique and successful handbook on the theory and practice of effective design of scientific experiments, based on a well-received course by the author. This second edition is entirely reorganized, rewritten, and includes new material and figures. The material is presented in seven parts: Philosophy of Scientific Experimentation, Mapping Out the Project, System Validation, Experimental Design, Examples, What Comes After, and Putting It All Together. Experimental Design for Biologists, Second Edition, is an essential source in designing a sound research plan, critical to the success of graduate students.