Bøger udgivet af Birkhauser Verlag AG

This volume provides a comprehensive, state-of-the art review of the field of cell therapy.

Chapters cover fields related to fractals such as harmonic analysis, multifractal analysis, geometric measure theory, ergodic theory and dynamical systems, probability theory, number theory, wavelets, potential theory, partial differential equations, fractal tilings, combinatorics, and signal and image processing.

This book shows the importance of studying semilocal convergence in iterative methods through Newton's method and addresses the most important aspects of the Kantorovich's theory including implicated studies.

In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed.

This book investigates the convergence and summability of both one-dimensional and multi-dimensional Fourier transforms, as well as the theory of Hardy spaces.

There are several physico-chemical processes that determine the behavior of multiphase fluid systems ¿ e.g., the fluid dynamics in the different phases and the dynamics of the interface(s), mass transport between the fluids, adsorption effects at the interface, and transport of surfactants on the interface ¿ and result in heterogeneous interface properties. In general, these processes are strongly coupled and local properties of the interface play a crucial role. A thorough understanding of the behavior of such complex flow problems must be based on physically sound mathematical models, which especially account for the local processes at the interface.This book presents recent findings on the rigorous derivation and mathematical analysis of such models and on the development of numerical methods for direct numerical simulations. Validation results are based on specifically designed experiments using high-resolution experimental techniques. A special feature of this book is its focus on an interdisciplinary research approach combining Applied Analysis, Numerical Mathematics, Interface Physics and Chemistry, as well as relevant research areas in the Engineering Sciences. The contributions originated from the joint interdisciplinary research projects in the DFG Priority Programme SPP 1506 ¿Transport Processes at Fluidic Interfaces.¿

This book focuses on the interplay between Eulerian and Lagrangian conservation laws for systems that admit physical motivation and originate from continuum mechanics.

A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays.

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art techniques and methods and relevance to human disease. Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are interested in experimental model systems for insight into ARDS pathogenesis and treatment strategies. ¿

This book is a collection of papers presented at the "Archimedes in the 21st Century" world conference, held at the Courant Institute of Mathematical Sciences in 2013.

This volume presents a collection of contributions that were published in "Pure and Applied Geophysics - pageoph" and which deals with the major earthquake that hit Illapel, Chile on September 16, 2015 with magnitude 8.3, and associated trans-oceanic tsunami.

The author, an accomplished female mathematician, achieves this by taking a problem solving approach, starting with fascinating problems and solving them step by step with clear explanations and illuminating diagrams.The reader will find the problems interesting, unusual, and fun, yet solved with the rigor expected in a competition.

This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo.

This is a collection of new investigations and discoveries on the theory of opposition (square, hexagon, octagon, polyhedra of opposition) by the best specialists from all over the world.

This book marries stem cell biology, tissue engineering, and regenerative biology into a single, interdisciplinary volume.

A vital text that collates a wealth of previously dispersed material on the derivation and analysis of fluid models in plasma physics, this stimulating introduction to the topic deploys rigorous asymptotic analysis to justify classical physical approximations.

This contributed volume focuses on aspects of dynamic game theory including differential games, evolutionary games, and stochastic games.

This book provides an up-to-date description of the methods needed to face the existence of solutions to some nonlinear boundary value problems. In a paedagogical style the author takes the reader step by step from the basics to the most advanced existence results in the field.

This volume is dedicated to the eminent Georgian mathematician Roland Duduchava on the occasion of his 70th birthday. It presents recent results on Toeplitz, Wiener-Hopf, and pseudodifferential operators, boundary value problems, operator theory, approximation theory, and reflects the broad spectrum of Roland Duduchava's research.

This book examines the design of two care pathways to establish how key principles associated with systems thinking, quality improvement, and supply chain management can improve the design of these services.

Describing novel mathematical concepts for recommendation engines, Realtime Data Mining: Self-Learning Techniques for Recommendation Engines features a sound mathematical framework unifying approaches based on control and learning theories, tensor factorization, and hierarchical methods.

This volume offers the most comprehensive coverage on fetal programming. Chapters are written by authors of international and national standing, leaders in the field and trendsetters. The clinical relevance of the current research is emphasized in each chapter, which also contains key points, key words, and concise summaries for ease of learning. Fetal programming affects conditions in the immediate postnatal period, as well as in later life and adulthood. These conditions include cardiovascular disease, frank hypertension, stroke, dyslipidemia, coagulopathy, increased insulin resistance-metabolic syndrome, type-2 diabetes, leukemia, testicular cancer, prostate cancer, breast cancer, polycystic ovary syndrome, precocious puberty, impaired immune function, renal disease, lung disease, and osteoporosis. Neuropathologies, behavioral and mental deficiencies, schizophrenia, and depression have also been reported in adults who were exposed to nutritional inadequacies in utero. Diet, Nutrition and Fetal Programming provides an overview on the effects of fetal programming on disease, and comprehensive looks at maternal nutrition factors and fetal programming effects on brain and behavior, and physiology and disease. It also provides an in depth look at specific nutrient restrictions and supplements on physiology and disease, the effects of maternal disease on fetal programming, mechanisms of programming, and a special section on the international aspects and policies on fetal programming.

This book aims to face particles in flows from many different, but essentially interconnected sides and points of view. Thus the selection of authors and topics represented in the chapters, ranges from deep mathematical analysis of the associated models, through the techniques of their numerical solution, towards real applications and physical implications.The scope and structure of the book as well as the selection of authors was motivated by the very successful summer course and workshop "Particles in Flows'' that was held in Prague in the August of 2014. This meeting revealed the need for a book dealing with this specific and challenging multidisciplinary subject, i.e. particles in industrial, environmental and biomedical flows and the combination of fluid mechanics, solid body mechanics with various aspects of specific applications.

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses.

Maxim's vision has inspired major developments in many areas of mathematics, ranging all the way from probability theory to motives over finite fields, and has brought forth a paradigm shift at the interface of modern geometry and mathematical physics.