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Organic Synthesis, Fifth Edition provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, providing them with critical working knowledge of basic reactions, stereochemistry, and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. There have been advancements in organic reactions, particularly organometallic reactions, and there is a need to show how these advancements have influenced current organic synthesis. The goal is to revise and update the reaction examples taken from the synthesis literature from 2017 to 2023. The reactions illustrate those used most often in modern organic synthesis, but these new examples will show their current relevance. Where new approaches and reactions have been developed for organic synthesis, examples have been added as new material.

Advances in Computers, Volume 131 is an eclectic volume inspired by recent issues of interest in research and development in computer science and computer engineering. Chapters in this new release include eHealth: enabling technologies, opportunities, and challenges, A Perspective on Cancer Data Management using Blockchain: Progress and Challenges, Cyber Risks on IoT Platforms and Zero Trust Solutions, A Lightweight Fingerprint Liveness Detection Method for Fingerprint Authentication System, and Collaborating Fog/Edge Computing with Industry 4.0 ¿ Architecture, Challenges and Benefits, Raspberry Pi-s for Enterprise Cybersecurity Applications.

Advances in Applied Microbiology, Volume 125 continues the comprehensive reach of this widely read and authoritative review source in microbiology where users will find invaluable references and information on a variety of areas relating to the topics of microbiology.

Steroid Biochemistry, Volume 688 in the Methods of Enzymology series, highlights new advances in the field, containing chapters on a variety of timely topics, including Cytochrome P450 Enzyme, Steroidogenic P450s (CYP11A1, 17A1, 21A2, 11B1, and 11B5), Steroid 17 alpha-hydroxylase/17,20-lyase (Cytochrome P450 17A1), Enzymes of Estrogen Biosynthesis, Aromatase and Steroid Sulfatase, Estrogenic 17b-Hydroxysteroid Dehydrogenase, Hydroxysteroid Dehydrogenases (HSD), 3a-Hydroxyssteroid Dehydrogenase, Approaches to Measuring 3b-Hydroxysteroid Dehydrogenase Type 1, 3b-Hydroxysteroid Dehydrogenase Type 2, and much more.

Digital Technologies in Movement Disorders, Volume Five updates on the latest advances in new technologies for the care of common conditions, including Parkinson¿s disease and other diseases. The book has been organized in four differentiated sections with chapters that cover an Introduction, key concepts, and overview of digital solutions, Applications of AI in MD, Digital Biomarkers in MD, Sensors basic concepts for the MD specialist, Wearable systems in MD, Quantitative gait analysis, The challenges and opportunities of remote evaluation in MD, Telemedicine in MD, ePROs, eCOA and other digital health solutions, HIFU, Telerrehabilition and other therapeutical applications of technology, and more.

Starch-Based Nanomaterials for Food Packaging: Perspectives and Future Prospectus presents the properties and sources of starch- based nanomaterials, new perspectives, safety aspects, applications and future trends. The book's chapters cover nanostructured materials, polysaccharide based bionanocomposites, starch based nanofibers, starch food packaging applications, nano gold imprinted starch bio nanocomposites, cereal starch-based nanoparticles, and edible packaging reinforced with starch-based nanomaterials. This is a complete resource to food industrialists who deal directly with food packaging and fruit and vegetable preservation.

Advances in Genetics serial, Volume 110 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, all written by an international board of authors.

Advances in Genetics, Volume 109 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Epigenetic regulation of angiogenesis in tumor progression, RecBCD and Chi hotspots as determinants of self vs. non-self: A re-evaluation, Horizontal gene transfer to plants from Agrobacterium and related bacterial species, and more.

Digital Twin for Smart Manufacturing: Emerging Approaches and Applications provides detailed descriptions on how to integrate and optimize novel digital technologies for smart manufacturing. The book discusses digital twins, which combine the industrial internet of things, artificial intelligence, machine learning and software analytics with spatial network graphs to create living digital simulation models that update and change as their physical counterparts change. In addition, they provide an effective way to integrate technologies like cyber-physical systems into a smart manufacturing system, potentially optimizing the entire business process and operating procedure of the manufacturing firm. Drawing on the latest research, the book addresses the topics and technologies key to successful implementation of a smart manufacturing system, including augmented and virtual reality, big data and energy management. Broader subjects such as additive manufacturing and robotics are also covered in this context, covering every aspect of production.

Few students sitting in their introductory statistics class learn that they are being taught the product of a misguided effort to combine two methods into one. Few students learn that some think the method they are being taught should be banned. Wise Use of Null Hypothesis Tests: A Practitioner's Handbook follows one of the two methods that were combined: the approach championed by Ronald Fisher. Fisher's method is simple, intuitive, and immune to criticism. Wise Use of Null Hypothesis Tests is also a user-friendly handbook meant for practitioners. Rather than overwhelming the reader with endless mathematical operations that are rarely performed by hand, the author of Wise Use of Null Hypothesis Tests emphasizes concepts and reasoning. In Wise Use of Null Hypothesis Tests, the author explains what is accomplished by testing null hypotheses-and what is not. The author explains the misconceptions that concern null hypothesis testing. He explains why confidence intervals show the results of null hypothesis tests, performed backwards. Most importantly, the author explains the Big Secret. Many-some say all-null hypotheses must be false. But authorities tell us we should test false null hypotheses anyway to determine the direction of a difference that we know must be there (a topic unrelated to so-called one-tailed tests). In Wise Use of Null Hypothesis Tests, the author explains how to control how often we get the direction wrong (it is not half of alpha) and commit a Type III (or Type S) error.

Biosensors for Emerging and Re-Emerging Infectious Diseases provides a review of how cornerstone optical, electronic, nanomaterial and data processing technologies can address detection issues occurring in a pandemic event. This book gives insights into the fundamental physical, chemical and biological mechanisms needed for such a type of detection. The content covers potential biomarkers which can be used for the infectious disease diagnostic, helping readers find the appropriate approach for the diagnosis of infectious diseases. It presents a novel approach to transferring the sensing platform from lab to application in clinics and to point of care detection. The book then moves on to discuss the function and efficiency of the biosensing platform in early diagnosis of infectious diseases compared to the standard methods. The required time, the technician skills and the steps which must be performed are other key factors of the biosensing platform which are well explained.

Basic Life Science Methods: A Laboratory Manual for Students and Researchers presents forty of the most executed life science assays. The authors use a consistent structure to cover the preparation, execution and analysis of data from each method. Assays include estimation of cholesterol fractions, C-Reactive Protein, Genomic DNA isolation, Agarose Gel Electrophoresis, RT-PCR, DNA solution preparation, how to design primers, and enzyme-linked immunosorbent assay (ELISA). This book provides a complete reference containing step-by-step instructions on how to run life science assays. Laboratory staff can also benefit of the book as a training resource.

AI Assurance: Towards Trustworthy, Explainable, Safe, and Ethical AI provides readers with solutions and foundational understanding of the methods that can be applied to test AI systems and provide assurance. Anyone developing software systems with intelligence, building learning algorithms, or deploying AI to a domain-specific problem (such as allocating cyber breaches, analyzing causation at a smart farm, reducing readmissions at a hospital, ensuring soldiers' safety in the battlefield, or predicting exports of one country to another) will benefit from the methods presented in this book. AI assurance is now a major piece in AI and engineering research, and this book serves as a guide to researchers, scientists, and students in their studies and experimentation with AI. Moreover, as AI is being increasingly discussed and utilized at government and policymaking venues, the assurance of AI systems -as presented in this book- is at the nexus of such debates.

Viral Diseases of Field and Horticultural Crops details the fundamental and applied aspects of the viral diseases of field and horticultural crops. The book opens with a historical introduction to plant virology, important plant virologists, and landmarks. It continues with systematic coverage of viral diseases, their economic significance, disease symptoms, host range, mode of transmission, diagnostic techniques, geographic distribution, epidemiology, yield losses, and control and management of the disease. Contributions from an international group of virologists with a wide range of academic, research, professional, and specialized backgrounds in plant virology makes Viral Diseases of Field and Horticultural Crops a comprehensive and must-have resource for those engaged in the study and research of plant virology, microbiology, and plant pathology particularly viral diseases and their impact on field and horticultural crops.

MR Linac Radiotherapy: A New Personalized Treatment Approach comprises both clinical and physical aspects of this new technology. The book covers treatment planning, workflow and technical issues about MR-Linac. Specially, the clinical use of MR-Linac according to different cancer types is presented by experienced physicians. This is a unique guide for medical physicists, RTTs, dosimetrists and physicians, as well as radiation oncologists and their teams. The MR Linac combines two technologies - a magnetic resonance imaging scanner and a linear accelerator - to precisely locate tumors, tailor the shape of radiation beams in real-time, and precisely deliver doses of radiation, even to moving tumors. This highly innovative technology is very new, and the number of newly installed MR-Linac machines will gradually increase worldwide. However, as there is no published book as a guideline, this book will help new MR-Linac users and centers planning to have MR-Linac.

Advances in Cardiovascular Technology: New Devices and Concepts is a comprehensive reference for cardiovascular devices of all types. For engineers, this book provides a basic understanding of underlying pathologies and their prevalence/incidence. It also covers what devices are available, how they are clinically used, and their impact on pathophysiology. In addition, the book presents the constraints imposed on device design and manufacture by the environment in which it is used (e.g., exposure to tissues within the body, blood in particular) and the primary requirements for each specific type of device, including its durability and resistance to fatigue. For clinicians, this book contains information on primary engineering challenges, the types of devices available, their advantages and disadvantages, and the (current and emerging) tools and materials available to device designers.