Bøger af Stephan Blackwood

Hypoxia refers to a condition in which the body or some part of the body does not receive enough oxygen supply at the tissue level. It can be categorized as either generalized, where entire body is affected, or localized, where a part of the body is affected. It is a pathological condition including changes in the arterial oxygen concentrations. These types of changes can also occur during normal physiology, such as while doing vigorous physical activity and hypoventilation training. Hypoxia can be caused due to the failure in the delivery of oxygen to the cells. This condition results in increased heart rate and aortic blood flow, and it decreases the peripheral resistance. Oxygen supply and blood flow is increased towards the vital organs, which is an indicator that redistribution of blood flow is essential for the oxygen supply. This book unravels the recent studies on hypoxia and circulation. It consists of contributions made by international experts. This book will serve as a valuable source of reference for graduate and post graduate students.

Hypoxia is referred to as the condition of low oxygen level and it occurs naturally in high altitudes. As the altitude rises, total atmospheric pressure falls down and causes a lower partial pressure of oxygen causing hypobaric hypoxia. The humans have adjusted themselves to hypoxia that occurs at high altitude in various locations, which is possible due to genetic basis. The genetic signatures of certain populations are recognized in the hypoxia-inducible factor (HIF) pathway, responsible for the organization of transcriptional response to hypoxia. These genetic signatures are found in the HIF2A gene in Tibetans, which encodes for the prolyl hydroxylase domain protein 2 and HIF-2α gene. Adaptation to high altitude is the result of various genes that act in coordination with each other. Novel therapeutic approaches can be identified by unraveling the mechanisms of these genes. This book provides comprehensive insights on hypoxia. It will help the readers in keeping pace with the rapid developments in the study of human adaptation to hypoxia.