Bøger af Rudyard Ramsey

An intrinsically disordered protein (IDP) is a protein in which the fixed or ordered three-dimensional structure is absent, generally when its macromolecular interaction partners, such as other proteins or RNA are absent. The flexible structure of these proteins allows them to accomplish their biological functions. IDPs play an important role in DNA regulation and cell signaling owing to their ability to participate in weak multivalent interactions that are highly cooperative and dynamic. There are various IDPs that can adopt a fixed three-dimensional structure after they bind themselves to other macromolecules. IDPs are associated with numerous diseases such as cancer, cardiovascular disease, amyloidoses, neurodegenerative diseases and diabetes. This book includes some of the vital pieces of works being conducted across the world, on various topics related to the relationship between intrinsically disordered proteins and diseases. Its extensive content provides the readers with a thorough understanding of the subject.

Intrinsically disordered proteins (IDPs) are a class of proteins that do not fold into a specific three-dimensional structure, which is a characteristic of proteins. The structural flexibility of IDPs range from fully structured to partially structured, which enables them to complement ordered proteins in order to perform functions that cannot be performed by rigid structures. Several factors such as pH and temperature can affect the shape and level of disorder in proteins. IDPs have been associated with various diseases such as cancer and cardiovascular diseases. The accumulation of an IDP called α-synuclein plays a pathophysiological role in Parkinson's disease (PD). The structural flexibility of the unstructured α-synuclein protein and associated disease mechanisms is affected by several factors such as genetics, oxidative stress, nitrative stress, and mitochondrial impairment. The book aims to shed light on some of the unexplored aspects of intrinsically disordered proteins and the recent researches on them. It will serve as a valuable source of reference for the graduate and postgraduate students.