Bøger af Rossen Donev

Hormones, Volume 142, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Estrogen receptor binding mechanism with agonist and antagonist, Biomarker Identification of Medullary Thyroid Carcinoma from Gene Expression Profiles Considering without-treatment and with-treatment Studies - A Bioinformatics approach, Exploring the Role of Estrogen and Progestins in Breast Cancer: A Genomic Approach to Diagnosis, Structural insights on ER-alpha, ER-Beta, progesterone and their drug-targets interactions in Breast cancer, The predictive ability of myokines in patients with chronic heart failure, and much more. Other chapters cover Endogenous and artificial regulators of pituitary glycoprotein hormone receptors, Insight into vitamin D3 action within the ovary - basic and clinical aspects, Hormonal basis of seasonal changes in metabolism, Viral mimicry and endocrine system: Divulging the importance in host-microbiome crosstalk, Recombinant hormones as biopharmaceuticals: past, present and future, Thyroid hormone biosynthesis and its role in brain development and maintenance, and much more.

Metalloproteins account for nearly half of all proteins in living organisms. Protein metal-binding sites are responsible for catalyzing some of the most important functions such as photosynthesis, respiration, water oxidation, molecular oxygen reduction, nitrogen fixation, etc. Motor proteins are another class of important proteins that can move along the cytoplasm of cells. They convert chemical energy into mechanical work by the hydrolysis of ATP. Much effort has been devoted toward understanding the structure and function of metalloproteins and motor proteins. The ultimate test is to utilize this knowledge to design new metalloproteins and motor proteins that reproduce structures and functions of native ones. While it is much more challenging to design these two groups of proteins compared to the rest of proteins, much progress has been made in this field, particularly toward functional design, thanks to recent progress in areas such as computational and structural biology. This thematic volume focuses on recent advances in studying metalloproteins and motor proteins, their roles in different pathologies and drug-resistance.