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For reasons of health and safety, all 2021 Harvard Summer School courses and activities will be offered online, and we will not be hosting a residential program for high school students. The feedback from our 2020 virtual programs from students and faculty was overwhelmingly positive, and we look forward to another exciting and successful summer online in 2021.The total fee for a Harvard Pre-College Program online session is $3,200. The program fee includes tuition and activity costs for the full two weeks. The breakdown of costs and additional fees is outlined below. In addition, we awarded a limited number of scholarships to students on the basis of financial need. Visit our Payment Options page for information on the forms of payment accepted. Application fee (nonrefundable): $75Full program fee: $3,200Financial Aid

Adenine Nucleotides play a major role in cellular metabolism and functions, serving as high-potential phosphate transfer compounds in energy metabolism and as substrates and co-factors for proteins involved in signal transduction. During the last few years definite advancement has been made in elucidating the molecular and genetic aspects of the enzyme involved in oxidative phosphorylation, the so-called FoFl H~-ATP synthase. Non-invasive NMR technologies have been developed to monitor in vivo the energy level of tissues based on determination of the concentrations of adenine nucleotides, phosphate and phosphate esters. Thus it became clear that the capacity of oxidative phosphorylation adapts itself to the ATP demand which changes continuously with the physiological state in various tissues. This is achieved by regulation of the enzyme activity as well as by regulation of its biogenesis. The reversible phosphorylation of proteins is re­ cognised as a major regulatory mechanism in eukaryotic as well as in prokaryotic cells for cellular signal transduction and control of gene expression, cell growth, differentation and oncogenesis. The same applies to the role played by cAMP. A further topic of growing interest concerns the discovery of the ATP binding cassette (ABC) superfamily of transport proteins which includes systems of primary importance in medicine such as the multi-drug resistance P glycoprotein, the cystic fibrosis transmembrane conductance regulator (CFTR) and the 70 kd peroxisomal membrane protein. Finally, much attention is being devoted in many laboratories to the molecular structure and role of ATP­ modulated channels.