Bøger af Min Li

The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies.

In this book, Li Min proposes a new paradigm for the foundation and emergence of the classical tradition in early China, from the late Neolithic through the Zhou period. Using a wide range of historical and archaeological data, he explains the development of ritual authority and particular concepts of kingship over time in relation to social memory. His volume weaves together the major benchmarks in the emergence of the classical tradition, particularly how legacies of prehistoric interregional interactions, state formation, urban florescence and collapse during the late third and the second millenniums BCE laid the critical foundation for the Sandai notion of history among Zhou elite. Moreover, the literary-historical accounts of the legendary Xia Dynasty in early China reveal a cultural construction involving social memories of the past and subsequent political elaborations in various phases of history. This volume enables a new understanding on the long-term processes that enabled a classical civilization in China to take shape.

Aesthetic Surgery of the Craniofacial Skeleton is a unique atlas presenting specific procedures for aesthetic craniofacial surgery in a comprehensive and easily understandable style.

Min Li and a panel of hands-on experimentalists detail state-of-the-art molecular techniques for studying NMDA ligand-gated ion channels and developing assays for nontherapeutic lead selection.