Bøger af Megan Durham

Tuberculosis (TB) refers to a type of infectious disease generally caused by Mycobacterium tuberculosis. Lungs are the primary target of this disease, but it can also affect the other parts of the body. It can be treated with a combination of antibacterial medications. However, the evolution of drug-resistant tuberculosis necessitates the development of effective, novel and safe drug regimens. Drug discovery and development is a difficult, expensive and time-consuming process. One of the popular frameworks used in drug discovery is model-informed drug discovery and development (MID3). It aims to provide an informative prediction of drug efficacy and exposure in people for choosing innovative anti-tuberculosis drug combinations. This book is compiled in such a manner, that it will provide in-depth knowledge about drug discovery for treating tuberculosis. Those with an interest in this area of pharmaceutical science would find it helpful.

Tuberculosis or TB is an infectious disease, which generally affects the lungs, but may affect other parts of the body as well. It is caused by the bacteria called Mycobacterium tuberculosis. Fever, night sweats, blood-containing sputum and weight loss are primary symptoms of TB. Most cases of TB do not exhibit symptoms and are called latent. However, nearly 10% of such latent infections lead to active disease, which can be fatal if not treated. A diagnosis of active TB requires culture and microscopic examination of bodily fluids, and chest X-rays. Latent TB can be diagnosed with the Mantoux tuberculin skin test. It is treated with isoniazid alone or in combination with rifampicin or rifapentine. Active TB treatment requires multiple antibiotics over a long period of time. This book provides a fair idea about tuberculosis and the recent advances in its diagnosis and treatment. It presents researches and studies performed by experts across the globe. For all those who are interested in this disease, this book can prove to be an essential guide.