Bøger af Malgorzata Lekka

The mechanical properties of cells can be used to distinguish pathological from normal cells and tissues in many diseases. This two-volume work outlines the physics behind cell and tissue mechanics, describe the methods which can be used to determine their mechanical properties, and present various diseases in which a mechanical fingerprint could be established. Vol. 1. Biomedical Methods. Vol. 2. Biomedical Applications.

This book presents a comprehensive description of the basic concepts of soft matter mechanics and of the nano- and microscale biomedical methods that allow characterizing the mechanical properties of cells and tissues.

This book is dedicated to the discussion of several biomedical applications of the mechanical phenotyping of cells and tissues to specific disease models. The topical chapters on mechanics in disease are preceded by chapters describing cell and tissue structure and their relationship with the biomechanical properties, as well as by the description of dedicated sample preparation methods for the nano- and microscale mechanical measurements.

This book is designed to be a practical textbook that teaches how to assess the mechanical characteristics of living, individual cells by AFM. Following a step-by-step approach, it introduces the methodology of measurements in the case of both determination of elastic properties and quantification of adhesive properties.