Bøger af Lida Murdock

Systems medicine refers to the study of the human body by incorporating environmental, physiological and biochemical interactions. It evaluates disease by the integration of large volumes of patient datasets, while offering the scope for personalizing healthcare strategies by developing a novel classification of disease. The redefinition of disease is done on the basis of mechanisms in place of analyzing the symptoms, which provide therapeutic targets, involving network pharmacology and drug repurposing. Network pharmacology is an interdisciplinary science based on pharmacology, network biology, systems biology, bioinformatics, computational science, and other related scientific disciplines. The usage of network-based insight allows network pharmacology to systematically reflect and uncover the biological foundation of complex diseases and medication. It uses a systems approach to generate significant insights for drug development and has the capability to serve as a foundation for developing drugs for complicated diseases. This book discusses the fundamentals as well as modern approaches of systems medicine and network-based pharmacology. Those in search of information to further their knowledge will be greatly assisted by it.

Network pharmacology is an emerging discipline focused on understanding drug interactions and actions within multiple targets. It systematically lists the molecular interactions of a drug that take place in a living cell, by making use of computational techniques. It studies the effect of a drug on the body and the biological system. It comprises chemical properties, sources, biological effects and use of drugs for therapeutics. Bioinformatics, high-throughput histology and system biology are utilized by network pharmacology, which combines information network and pharmacology. Pharmacokinetics and pharmacodynamics are the two main branches of pharmacology. Pharmacokinetics is concerned with the supply, absorption, metabolism and excretion of drugs, while pharmacodynamics is related with the physiological, molecular and biochemical effects of drugs. It integrates polypharmacology and network biology, which helps in the identification of drugs and disease targets, simultaneously understanding pathways and mechanisms between them. This book is a compilation of chapters that discuss the most vital concepts in the field of network pharmacology. The topics covered herein offer the readers new insights into this field.