Bøger af Erica Helmer

Pharmacokinetics (PK) determines the outcome of substances which are administered in the human body and involves drug absorption, distribution, metabolism, and excretion (ADME) processes. Drug absorption is the movement of drug in the bloodstream from its site of administration. It depends on multiple factors, including the formulation and chemical properties of a drug, drug-food interactions and route of administration. Drug distribution is essential for determining drug efficacy and drug toxicity. Drug metabolism is the chemical alteration of the drug by the body. Genetics, age and drug interactions are some factors that affect drug metabolism. In clinical use, an enzyme named cytochrome P450 (CYP450) is responsible for the biotransformation or metabolism of all drugs. It is essential to comprehend the basic mechanisms governing the pharmacokinetics of a drug for designing personalized course of therapy for patients. This book provides comprehensive insights into the role of pharmacokinetics and metabolism in drug design. It is appropriate for students seeking detailed information in this area of study as well as for experts.

Drug metabolism refers to the conversion of a drug molecule into other related compounds throughout the body. There are drug modifying enzymes (DME), such as cytochrome P450, which are involved in the modification of an administered drug during the process of drug metabolism. The liver is the primary organ involved in the modification and removal of drug compounds, along with numerous other locations within the body. The therapeutic efficacy of a drug is influenced by many factors, including pharmacokinetics. It refers to the passage of a drug through the body's biological system. There are four different phases in the passage of a drug in the human body, which includes absorption, distribution, metabolism, and excretion (ADME). These pharmacokinetic qualities collectively provide deeper insights into the performance of a drug and help to establish the optimal dosage. This book provides significant information to help develop a good understanding of drug metabolism and pharmacokinetics. It presents researches and studies performed by experts across the globe. This book aims to equip students and experts with the advanced topics and upcoming concepts in this area of study.