Bøger af Elena Poole

Alzheimer's disease (AD) refers to a progressive brain disease, which gradually destroys thinking skills and memory, as well as the capacity to perform even basic tasks. It is one of the leading causes of progressive dementia. There are several factors that contribute to the development of AD, but the most significant risk factor is aging. Intracellular neurofibrillary tangles and extracellular aggregates of amyloid β (Aβ) plaques made up of hyperphosphorylated τ-protein in limbic and cortical parts of the human brain have been linked to its pathogenesis. The biomarkers of AD are neurochemical indicators, which are utilized to determine the presence or risk of the disease. One of the well-recognized biomarkers of AD is amyloid beta (Aβ), which can be utilized to diagnose AD at an early stage in addition to tracking the progression of the disease. There is currently no cure for this disease and existing treatments provide only minor symptomatic relief, and are therefore considered palliative. This book contains some path-breaking studies related to Alzheimer's disease. It attempts to examine the risk factors, pathogenesis, biomarkers and potential treatment strategies related to Alzheimer's disease. Those in search of information to further their knowledge will be greatly assisted by this book.

Alzheimer's disease (AD) is a type of brain disorder that affects the memory and thinking abilities. It is a progressive condition that causes brain shrinkage and cell death. The major symptoms of Alzheimer's disease include memory problems, changes in personality and behavior, and mood swings. There is no specific cause for AD. A history of depression, hypertension and head injuries are some of the common risk factors associated with Alzheimer's disease. The diagnosis of AD is based on physical examination and neurological health assessment. The common diagnostic tests for AD include blood tests, brain imaging and PET scans. Treatment of AD includes medications to reduce the progression of cognitive decline. This book on Alzheimer's disease is a collective contribution of a renowned group of international experts. It strives to provide a fair idea about this medical condition and to help develop a better understanding of the latest advances within its clinical management.

Alzheimer's disease (AD) refers to a type of neurologic condition, which causes the brain to shrink and brain cells to die over time. AD is the most frequent form of dementia in which a progressive loss in social, cognitive and behavioral abilities occurs that impairs a person's capacity to operate independently. The primary symptom of AD is forgetting recent events or discussions. A person with AD will have severe memory impairment, while losing the capacity to perform daily tasks, as the disease progress. Drug development for AD relies heavily on biomarkers and they can also be used to facilitate diagnosis, safety monitoring, demonstrating target engagement and supporting the modification of disease. AD is incurable due to its multifactorial and complex nature. Biomarkers aid in characterizing the baseline state, a therapy response or a disease process. This book is compiled in such a manner, that it will provide in-depth knowledge about the assessment and management of Alzheimer's disease. It presents researches and studies performed by experts across the globe.

Neurodegeneration refers to a progressive loss of function and structure of neurons. It is observed at different levels of neuronal circuitry from molecular to systemic. Several manifestations of neurodegeneration are amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease and Huntington's disease, among others. In the pursuit of effective therapies that can stop or reverse neurodegeneration, animal models of disease are being used to test potential therapeutic agents. These facilitate target identification and validation. Upregulation of autophagy and protein degradation are certain therapeutic strategies that are being actively pursued. This book aims to shed light on some of the unexplored aspects of neurodegeneration and the recent researches in this field. It consists of contributions made by international experts. This book aims to equip students and experts with the advanced topics and upcoming concepts in this area.

Neurodegeneration is the gradual loss of neurons, and neuronal structure and function. This is the cause of neurodegenerative diseases, such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, etc. Research in neurodegeneration suggests that there exists several similarities between these disorders such as induced cell death and atypical protein assemblies. DNA damage accumulation has been proposed to be the causative link between neurodegeneration and aging. Several mechanisms have been implicated in the occurrence and progression of neurodegeneration, such as protein misfolding, programmed cell death, genetic mutations, various intracellular mechanisms, etc. Protein degradation is a therapeutic option for preventing the synthesis and degradation of irregular proteins that are formed in neurodegenerative disease. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in neurodegeneration. Different approaches, evaluations and advanced studies have been included herein. The extensive content of this book provides with a thorough understanding of the subject.