Bøger af Ashok Agarwal

Infertility is an important public health problem affecting around 15% of couples worldwide. A male factor contributes to about 50% of all cases of infertility. Male infertility could be related to a variety of congenital or acquired causes that lead to abnormal reproductive potential and poor sperm quality and function. To this date, semen analysis remains the cornerstone of male infertility evaluation. Clinicians widely reference the World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen, which provides a detailed description of a variety of semen tests. However, the manual does not provide a sufficient clinical context for the various tests that are described.This book is intended to bridge the gap between the laboratory manual and the clinician by explaining in detail the test indication, its clinical utility, interpretation of results, and presenting a decision algorithm based on the test results. Thebook has 19 chapters grouped under seven sections that follow the chapters of the sixth edition of the WHO manual. Each chapter is written and reviewed by a team of senior clinicians, thus bringing a perspective that is truly clinically relevant. This book will be of great value to all clinicians involved in the management of male infertility and will also be of interest to laboratory scientists involved in semen testing by providing them with clinical perspectives of the test they perform. Human Semen Analysis: From the WHO Manual to the Clinical Management of Infertile Men is a useful guide for utilizing the WHO manual, interpreting test results, and deciding what subsequent clinical actions to take.

Despite the fact that about half of infertility problems stem from male factors, gynecologists are often the first health care providers to perform the initial assessment of the infertile couple. For this reason, it is critical that gynecologists and reproductive medicine specialists remain up to date on the primary conditions that cause male infertility, as well as current diagnostic tools and treatment options of both natural and assisted conception. From diagnosis through treatment, Male Infertility: Management of Infertile Men in Reproductive Medicine offers expert, straightforward guidance on the pathophysiology and management of male infertility for clinicians who assist couples early in the process of trying to conceive.Covers diagnostic aspects of male infertility (clinical, laboratory, and imaging methods) as well as various therapeutic options including classical and advanced surgical procedures.Discusses intrauterine insemination, conventional in vitro fertilization, intracytoplasmic sperm injection, sperm cryopreservation, preimplantation genetic testing, and more.Begins each chapter with key points and ends with clinical scenarios of real-life problems and their solutions.Shares the knowledge and expertise of global experts in the field.An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Any additional digital ancillary content may publish up to 6 weeks following the publication date.

This book discusses the various antioxidants that are in use to overcome oxidative stress in an assisted reproduction setting. Antioxidant therapies may range from enzymatic and non-enzymatic antioxidants, either alone or in combination. While no one antioxidant regime has been identified as effective in improving fertilization and pregnancy rates, antioxidant supplementation has been shown to defend sperm cells from lipid peroxidation and oxidative damage to DNA, and thus improve pregnancy rates. The prevention of oxidative stress and its consequent damage is imperative to ensure a successful outcome of the in vitro fertilization procedure and embryo transfer. Strategies that could be employed to minimize or prevent the detrimental effects of OS during assisted reproduction include supplementation with various types of antioxidants.

This Brief explores the use of proteomics as a tool for biomarker discovery in human reproduction and summarizes current findings and trends of proteomic studies in both male and female infertility.

Compilation of information from 'Human Spermatozoa and Assisted Conception' 2011 training workshop, with contributions from international ART experts.