Bøger af Anthony C Atkinson

The International Statistical Institute was founded in 1885 and is therefore one of the world's oldest international scientific societies. The field of statistics is still expanding rapidly and possesses a rich variety of applications in many areas of human activity such as science, government, business, industry, and everyday affairs. In consequence, the celebration of the Institute's centenary in 1985 is of considerable interest not only to statisticians but also more widely to the international scientific community. As part of its centennial celebration planning the Institute decided to publish a volume of papers representing the immensely wide range of interests encompassed by statistics in its international context, viewed both from a historical and from a contemporary standpoint. We were fortunate in securing the services of Anthony Atkinson and Stephen Fienberg as Editors of this volume: they have worked hard over a period of several years to put together a most fascinating collection of papers. On behalf of the Institute it is my pleasant duty to thank them and the authors for their contributions. J. DURBIN, President International Statistical Institute Preface The papers in this volume were prepared to help celebrate the centenary of the International Statistical Institute. During the lSI's first 100 years statistics has matured, both as a scientific discipline and as a profession, in ways that the lSI's founders could not possibly have imagined.

Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.

Response-adaptive designs, which aim to reduce the number of patients receiving inferior treatments, are popular in Phase III clinical trials. This book provides an overview of the research in this area.