Bøger i Wiley Series in Drug Discovery and Development serien

This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery.

HYDROGEN SULFIDECovers H2S interactions, methods of detection and delivery in biological environments, and a wide range of applicationsResearch on hydrogen sulfide (H2S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H2S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H2S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities.Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies provides the foundation required for understanding the fundamental chemical biology of H2S while highlighting the compound's therapeutic potential and medicinal applications. This book covers key aspects of H2S chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H2S in biological environments; and the therapeutic and medicinal uses of exogenous H2S delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field.* Provides approaches for delivering H2S with relevance to biological and therapeutic applications* Describes complex interactions of H2S with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species* Summarizes advances in available tools to detect, measure, and modulate H2S levels in biological environments, such as real-time methods for H2S fluorescence imaging in live cell and animal systems* Helps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action* Includes in-depth case studies of different systems in which H2S plays an important roleHydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.

DRUG TRANSPORTERSDrug transporter fundamentals and relevant principles and techniques, featuring new and expanded chaptersDrug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases.* Reflects the current state of the field and offers perspectives on future directions* Covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science* Provides up-to-date information on drug transporter families, mechanisms, and clinical implications* Includes extensive references and numerous figures and tables throughoutUnderstandable for novices while offering sufficient depth for more experienced researchers, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.

CARBON MONOXIDE IN DRUG DISCOVERYAn insightful reference for the latest physiological and therapeutic studies of carbon monoxideIn Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential, a team of distinguished authors delivers foundational knowledge, the latest research, and remaining challenges regarding the physiological roles and therapeutic efficacy of carbon monoxide (CO). The editors have included a broad selection of resources from leading experts in the field that discuss the background and physiological roles of CO, a variety of delivery forms including CO prodrugs using benign carriers, CO sensing, therapeutic applications, and clinical trials.Organized by topic to allow each chapter to be read individually, the book covers a wide range of topics, from physiological and patho-physiological mechanisms at the molecular level to clinical applications for multiple disease processes.The editors of Carbon Monoxide in Drug Discovery have created a compelling argument for shifting the accepted understanding of CO from poison to bioactive molecule with enormous clinical benefits. Readers will also benefit from:* A thorough introduction to the background and physiological actions of carbon monoxide, including endogenous CO production in sickness and in health* Comprehensive explorations of CO delivery forms, including non-carrier formulations, metal-carbonyl complexes, and organic CO donors* Practical discussions of carbon monoxide sensing and scavenging, including fluorescent probes for intracellular carbon monoxide detection* In-depth examinations of the therapeutic applications of CO, including CO in solid organ transplantationPerfect for professors, graduate students, and postdocs in the fields of biology, pharmacology, immunology, medicinal chemistry, toxicology, and drug delivery, Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential is also an invaluable resource for industrial scientists in these areas.

Nucleic Acids in Medicinal Chemistry and Chemical BiologyAn up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applicationsIn Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers.The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field.Readers will also find:* A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry* Comprehensive explorations of the methods used to determine the development of nucleic acid drugs* Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries* In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistryPerfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Chemosensors?organic molecules designed to bind and sense small molecules or metal ions?function as molecular-level sensors that generate a signal upon binding.

Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference.

Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, this book overviews plant biodiversity as a source of new drugs and drug discovery strategies.

This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage.

Understanding bioavailability is critical to determining the amount of a drug to administer.

This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents.

Covering all areas of the medicinal chemistry and therapeutic applications of nucleic acids, this book provides up-to-date coverage of the broad area of nucleic acid chemistry and biology.

Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment.

Kinase Inhibitor Drugs covers a wide and comprehensive range of topics about kinase-targeted inhibitors in cancer therapy, one of the hottest drug targets in modern drug discovery.

Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market.

Both a reference source for researchers and a text for graduate students investigating the various aspects of the dopamine transporter (DAT), Dopamine Transporter: Chemistry, Biology, and Pharmacology includes aspects of chemistry, biology, and pharmacology and provides a strong general overview of this neurotransmitter.

GSK-3 is a promising drug target that has been extensively tested, and shown great potential for treatment of diseases that have no current effective treatment - like Alzheimer's, bipolar disorder, and cancer.

Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention.

This book gathers present knowledge on the involvement of ABC transporters in drug transport and resistance. Bringing together updated information from an otherwise-scattered field of scientific literature, this resource helps researchers in pharmaceutical science in discovering drugs able to counteract multidrug resistance in diseases like cancer.

Studies of vaccines derived from carbohydrate antigens have seen great progress. Synthetic carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids, have been explored or used to prevent and treat bacterial and viral infections, cancer, and other diseases.

Computer Applications in Pharmaceutical Research and Development analyzes the use of computers through the entire pharmaceutical process of discovering, developing, and marketing new medicines.

This book focuses on the formulation and delivery of dendrimers. It offers both a comprehensive introduction and reference to practical applications. The coverage encompasses dendritic drug delivery systems ranging from dendrimers chemistry to cellular uptake of dendritic nanoparticles.