Bøger i The Receptors serien

This comprehensive review deals with all aspects of Tachykinin receptors in particular, and with neuropeptide/peptide and G-protein linked receptors in general. This book should be of interest to pharmacologists, neuroscientists, biochemists, toxicologists, and molecular and cellular biologists.

G-protein coupled receptors (GPCRs) constitute a large superfamily of proteins that have been historically well represented as drug targets. As such, many of the volumes within The Receptors series have focused their attention on rec- tor subfamilies in the GPCR superfamily (e. g. , adrenergic, serotonergic, do- minergic). While chemokine receptors are relatively young, in terms of the knowledge that has accumulated regarding their roles in physiology and pat- logy, it is clear that this GPCR subfamily is dwar? ng all others with respect to the total number of receptors and their functional diversity. The breadth of the chemokine ? eld was not fully appreciated in the early days of chemokine d- covery, when the characterization of these molecules was largely a curiosity of a small set of biologists primarily interested in in? ammation. Presently, the ? eld of chemokinology is quite diverse, and it is nearly impossible to stay informed on all aspects of chemokine biology. Nonetheless, this book seeks to distill information regarding the molecular and cell biology, physiology, and pathology of chemokines and their receptors into a single volume, providing an excellent resource for those entering the ? eld or the most experienced c- mokinologist seeking new insights. In the chapters, leading authorities consider structural and cellular aspects of chemokines and chemokine receptors, and more notably, discuss the roles of these molecules in a variety of disease states that transcend their classically de? ned role(s) in in? ammation.

As sites of action for drugs used to treat schizophrenia and Parkinson's disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders.

The Ghrelin receptor was identified before its natural ligand ghrelin.

An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings.

Here, experts introduce the field with chapters covering, among other subjects, cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of cannabinoid receptors, and the therapeutic applications for cannabinoid drugs.

Roger Cone and a distinguished team of expert investigators provide the first major treatment of this critically important receptor family. Topics include the characterization of the melanocortin receptors, the biochemical mechanism of receptor action, and receptor function and regulation.

A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors.

Here, experts introduce the field with chapters covering, among other subjects, cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of cannabinoid receptors, and the therapeutic applications for cannabinoid drugs.

Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

As sites of action for drugs used to treat schizophrenia and Parkinson's disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders.

Roger Cone and a distinguished team of expert investigators provide the first major treatment of this critically important receptor family. Topics include the characterization of the melanocortin receptors, the biochemical mechanism of receptor action, and receptor function and regulation.

Fifteen contributed articles by investigators survey the dramatic increase in the understanding of receptor action that has resulted from the recent cloning of numerous ionotropic glutamate receptor subunits.

A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors.

A comprehensive and up-to-date review of all literature concerning metabotropic glutamate receptors. It covers the molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles of these receptors.

Part of Springer's "The Receptors," series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors.

Research on muscarinic receptors is advancing at an extraordinary rate. The discovery that pirenzepine recognized apparent heterogeneity in muscarinic binding sites infused new life into the problem of subclassifying muscarinic receptors.

This volume, new to The Receptors series, focuses on several areas, including the birth, maturation, and structure of Chemokines; In particular the book contains cutting-edge information ranging from basic molecular and cellular mechanisms to physiological and pathological roles of chemokines.

Serotonin (5-HT) was isolated and chemically characterized nearly four decades ago, and is now generally accepted to function as a neurotransmitter and neuromodulatory agent. As the first of what we can expect to be a steady stream of monographs focusing on 5-HT receptors, the book confirms that we are in an exciting time in the history of 5-HT.

A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets.

This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student.

The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors.

This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student.

The study of these molecules, which may well include such diverse items as the receptors for hormones, neurohumors, pheromones, taste, and many other chemical signals, have a great deal in common, so that the student of any one of them will wish to know the status of research about the others.

This book is intended as a scientific resource for cannabinoid researchers carrying out animal and human experiments, and for those who are interested in learning about future directions in cannabinoid research.

During the past decade, great strides have been made in our un derstanding of the biochemistry and pharmacology of the alpha-l adrenergic receptor.

The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors.