Bøger i Reviews of Physiology, Biochemistry and Pharmacology serien i rækkefølge

This text provides an overview of late-1990s developments in the fields of physiology, biochemistry, and pharmacology. It focuses particularly on the effects of ageing on thymic development and T cell immunity, ageing and chromosomal instability, and voltage-dependent calcium channels.

This volume of "Reviews of Physiology" contains three contributions, on Selenium-containing proteins in mammals and other forms of life, on constitutively active and G-protein coupled inward rectifier K+ channels and on Chloroplast quest - a journey from the cytosol into the chloroplast and beyond.

With contributions by numerous experts

H. Wegele, L. Muller, and J. Buchner: Hsp70 and Hsp90 - A Relay Team for Protein Folding R. Schulein: The Early Stages of the Intracellular Transport of Membrane Proteins: Clinical and Pharmacological Implications L. Schild: The Epithelial Sodium Channel: From Molecule to Disease

H. Wegele, L. Muller, and J. Buchner: Hsp70 and Hsp90 - A Relay Team for Protein Folding R. Schulein: The Early Stages of the Intracellular Transport of Membrane Proteins: Clinical and Pharmacological Implications L. Schild: The Epithelial Sodium Channel: From Molecule to Disease

Recruitment of Hsp70 chaperones: a crucial part of viral survival strategies.- Molecular mechanisms of membrane polarity in renal epithelial cells.- Pharmacological properties of Cerium compounds.

Special Issue on Sensory Systems

Special Issue on Sensory Systems

The eukaryotic translation machinery must recognize the site on a messenger RNA (mRNA) where decoding should begin and where it should end. The selection of the translation start site is generally given by the ?rst AUG codon encoding the amino acid methionine. D- ing initiation soluble translation initiation factors (eukaryotic translation initiation factors [eIFs] in eukaryotes and prokaryotic translation initiation factors [IFs] in prokaryotes) bind the mRNA, deliver the initiator Met-tRNA, and assemble to form a complete 80S ribosome from the 40S and 60S subunits. By progressing along the mRNA in the 5 -to-3 direction the ribosome decodes the information and translates it into the polypeptide chain. During this process, repeated delivery of amino-acyl tRNA (aa-tRNA) to the ribosome, peptide bond formation, movement of the mRNA, and the growing peptidyl-tRNA is mediated by both soluble elongation factors (eukaryotic translation elongation factors [eEFs] in euka- otes and prokaryotic translation elongation factors [EFs] in prokaryotes) and the activity of the ribosome. The ?nal step in the translation process occurs when one of the three t- mination codons occupies the ribosomal A-site. Translation comes to an end and soluble release factors (eukaryotic translation termination factors [eRFs] in eukaryotes and proka- otic translation termination factors [RFs] in prokaryotes) facilitate hydrolytical release of the polypeptide chain (for recent reviews, see Inge-Vechtomov et al. 2003; Kisselev et al. 2003; Wilson and Nierhaus 2003; Kapp and Lorsch 2004).

This process is fa- + + cilitated by activation of the gastric H ,K -ATPase, which translocates to the apical pole of + - the parietal cell.

E. Bettiol, S. Clement, K.H. Krause, and M.E. Jaconi: Embryonic and Adult Stem-Cell Derived Cardiomyocytes: Lessons from in vitro ModelsN. Toda, K. Ayajiki: Phylogenesis of Constitutively Formed Nitric Oxide in Non-MammalsS. Huang and J. Wikswo: Dimensions of Systems BiologyS. C. Sinha and S.R. Sprang: Structures, Mechanism, Regulation and Evolution of Class III Nucleotidyl Cyclases

Contents E.I. Christensen and R. Nielsen: Role of Megalin and Cubilin in Renal Physiology and Pathophysiology G. Zifarelli and M. Pusch: CLC Chloride Channels and Transporters: A Biophysical and Physiological Perspective S.F.J. van de Graaf, R.J.M. Bindels and J.G.J. Hoenderop: Physiology of Epithelial Ca2 and Mg2+ Transport

Contents E.I. Christensen and R. Nielsen: Role of Megalin and Cubilin in Renal Physiology and Pathophysiology G. Zifarelli and M. Pusch: CLC Chloride Channels and Transporters: A Biophysical and Physiological Perspective S.F.J. van de Graaf, R.J.M. Bindels and J.G.J. Hoenderop: Physiology of Epithelial Ca2 and Mg2+ Transport

Contents Philip C. - Marilena Kampa, Artemissia-Phoebe Nifli, George Notas, Elias Castanas: Polyphenols and Cancer Cell Growth. - Michal Janitz: Assigning Functions to Genes - The Main Challenge of the Post-Genomic Era. - Brigittte M. Jockusch, Kai Murk and Martin Rothkegel: The Profile of Profilins.

Contents Philip C. - Marilena Kampa, Artemissia-Phoebe Nifli, George Notas, Elias Castanas: Polyphenols and Cancer Cell Growth. - Michal Janitz: Assigning Functions to Genes - The Main Challenge of the Post-Genomic Era. - Brigittte M. Jockusch, Kai Murk and Martin Rothkegel: The Profile of Profilins.

Reviews of Physiology, Biochemistry and Pharmacology Volume 160 2008 V. di Marzo: Endocannabinoids: Synthesis and Degradation R. Rivera and J. Chun: Biological Effects of Lysophospholipids S. J. O'Meara, K. Rodgers, and C. Godson: Lipoxins: Update and Impact of Endogenous Pro-Resolution Lipid Mediators R.K.P. Benninger, M. Hao, and D. Piston: Multi-photon Excitation Imaging of Dynamic Processes in Living Cells and Tissues G. Schmitz and M. Grandl: Lipid Homeostasis in Macrophages - Implications for Atherosclerosis

Reviews of Physiology, Biochemistry and Pharmacology Volume 160 2008 V. di Marzo: Endocannabinoids: Synthesis and Degradation R. Rivera and J. Chun: Biological Effects of Lysophospholipids S. J. O'Meara, K. Rodgers, and C. Godson: Lipoxins: Update and Impact of Endogenous Pro-Resolution Lipid Mediators R.K.P. Benninger, M. Hao, and D. Piston: Multi-photon Excitation Imaging of Dynamic Processes in Living Cells and Tissues G. Schmitz and M. Grandl: Lipid Homeostasis in Macrophages - Implications for Atherosclerosis

Kurtz: Regulation of Renin Release by Local and Systemic FactorsM. Haucke: Shaping Membranes for EndocytosisB.M. Jockusch and P.L. Graumann: The Long Journey: Actin on the Road to Pro- and Eukaryotic CellsB. Colsoul, R. Nilius: Transient Receptor Potential (TRP) Cation Channels in Pancreatic ss cells

Kurtz: Regulation of Renin Release by Local and Systemic FactorsM. Haucke: Shaping Membranes for EndocytosisB.M. Jockusch and P.L. Graumann: The Long Journey: Actin on the Road to Pro- and Eukaryotic CellsB. Colsoul, R. Nilius: Transient Receptor Potential (TRP) Cation Channels in Pancreatic ss cells

The highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology.