Bøger i Handbook of Experimental Pharmacology serien

Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 . . . . . . . . . . . . . . . Mast Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 . . . . .

Covered are the pharmacology of the parietal cell and the latest hypotheses for the development of acid-peptic disease including epidermal growth factor, gastrin and other peptide hormones, fatty acids and prostaglandins, helicobacter pylori, and gastric acid hypersecretion including Zollinger-Ellison syndrome.

Authored by an array of internationally distinguished scientists, it deals with issues of peptide localization and biosynthesis in gastrointestinal cells, mechanisms of peptide release and inactivation and the nature of peptide receptors.

The authors, all accomplished and world-renowned experts in their topic areas, have provided controversial and up-to-date accounts of the current status of research in calcium and bone metabolism by reviewing major areas of basic science which have an impact on the understanding of bone diseases and related disorders.

In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology.

This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.

with contributions by numerous experts

Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches uti- lized intracellularly in biological systems. The origins of the GTPase switch appear to be almost as ancient as life it- self, and through evolution nature has adapted this switch to a variety of purposes. In this two-volume work a broad survey of the major classes of GTPases is presented. The role of GTPases in ensuring ac- curacy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer, are all described in 80 chapters by the leading authorities in their fields. Both detailed knowledge of specific systems or proteins and general principles of structure and function are offered. Much of this information has never been published before. At the rate the extended family of GTPases is growing it becomes increasingly unlikely that we will again get it to sit for a group portrait such as this. Therefore, the volume has the chance to become t h e reference work for GTPases.

This book is an update of the treatment of hyperlipidemia, necessary due to the identification in recent years of molecular mechanisms of atherogenesis. Emphasis is on the disease etiology of arteriosclerosis, the treatment of associated or causing diseases and treatment by dietary means or hypolipidemic drugs.

This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents.

Comprehensive in its scope, this book provides an up-to-date, in-depth treatment of the field, with particular emphasis on the integration of research findings from diverse approaches and how these findings might influence future investigations.

A comprehensive and systematic survey of the present knowledge of the structure and physiological functions of smooth muscle and its response to endogenous substances and pharmacological agents.

The book also has chapters on emerging conceptual problems including resistance to metal toxicity effects on gene expression, alongside principles regarding drug-chelation of metals, the potential use of prophyrins as indicators of metal exposure and toxicity.

It was found that such essential functions as the flow of pancreatic juice and emptying of bile into the intestine were regulated by two hormones, secretin and cholecystokinin, respectively. In spite of the difficulties in obtaining secretin American authors succeeded in keeping the interest in the secretin test alive.

With contributions by numerous experts

This volume describes the present state of the art in carcinogenesis, possibilities for cancer prevention, and gives genetic background in cancer development. Attention is given to the host-environment interaction, considering how this interaction may lead to cancer formation and how it can be utilised in cancer prevention.

Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide.

The degree to which man is malleable and perfectible by social forces is not known nor do we know the true desirability of socializing individuals to the extent that their behavior does not deviate from social norms.

Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts.

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Absorption from the Stomach . . . . . . . . . . . . . . . . . . Intestinal Absorption of Macromolecules . Active Transport across the Intestinal Epithelium . Effect of EDTA on Drug Absorption from the Intestine .

With contributions by numerous experts

With contribution by numerous experts

with contributions by numerous experts

with contributions by numerous experts

A review of the current state of the clinical and basic science of the pharmacology of sleep. For the first time in one single volume, both the basic mechanisms of sleep, and the basic and clinical aspects of the pharmacology of sleep are dealt with in a thorough, comprehensive and authoritative manner.

with contributions by numerous experts

Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed.

With contributions of numerous experts.