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Proceedings of the Twenty-Eighth International Symposium on Blood Transfusion, Groningen, NL, Organized by the Sanquin Division Blood Bank North-East, Groningen.It is in many ways fitting that the last of these international symposia on blood transfusion should end with neonatal blood transfusion. The most fragile, least well studied and most at risk population requires special care and concern. We need to expand our knowledge of their unique physiology, biochemical pathways and in planning treatment and interventions, always "e;do no harm."e; This proceedings of the last Groningen symposium presents a wealth of information on developmental immunology, the molecular basis of haematopoeisis, physiological basis of bleeding and thrombosis, transfusion risks and benefits and lastly, future therapies. Infants provide us with much to learn but in turn they will be the providers of (through cord blood) and the recipients of (through cellular engineering) the best that science can offer. Translational research, which has been the thrust of these presentations for 28 years, will benefit them in a way that no scientist could have ever predicted.

As a clinical discipline blood transfusion encompasses enormous vista, vary­ ing from biotechnology to molecular biology, from plasma products, cell biology and growth factors to interleukines. Growth of knowledge in this field has been rapid, and expertise is now required to be mastered and renewed in translating these ideas for patient care. Various types of cells could be harvested - progenitor stem cells derived from bone marrow or from circulating blood as a source for transplants; in the hemostatic armoury platelets could be used prophylactically; granulocytes and mononuclear cells are available for treatment of infections or immune modulations. However, their therapeutic use carries potential complications including graft versus host disease and CMV-infection. Prevention of such complications by irradiation and by removal of immunocompetent leukocytes are important issues. Thus, production of such therapeutic materials ought to address the issues at the earliest, to eliminate those problems while adhering to the con­ cept of high quality; the impact of storing platelets for longer periods by using improved plastic containers or storing almost indefinitely in frozen state should be explored. Rapid progress in cell culture techniques and bio­ technology have enriched the transfusion medicine armoury with lympho­ kines, interferons and cell colony growth factors which have great potentials for enhancement of basic knowledge as well as considerable therapeutic applications in patients.

Proceedings of an interdisciplinary meeting, sponsored by the Commission of the European Communities, as advised by the Committee on Medical and Public Health Research

The first International Meeting on Apheresis was held in Dyon in 1984. At the congress it became clear that both the technical and therapeutic sides developed very rapidly and it appeared fruitful to bring together the investigators of the different countries working in the areas. At that time immunology had come to pervade many clinical specialities, and hemapheresis, especially plasmapheresis was considered a therapeutic tool in many immunological diseases which hitherto had proved to be fatal. New methods to identify certain antibodies and circulating immune complexes in the serum and the possibilities to remove them from the blood by several techniques (filtration, centrifugation, immunoabsorp­ tion) led to an almost uncontrolled use of plasma exchange in a variety of diseases. Since then the technical possibilities of this technique were further recognized, as was the impact of immunology on many diseases, and the possibilities to collect specific components for therapeutic pur­ poses. But also we became aware of the limited contributions of anec­ dotal data on successes or failures of apheresis as adjuvant treatment. Therefore international prospective studies were initiated to make critical assessment possible of apheresis in various diseases.

Although leprosy is mainly known as an "import" disease in Europe and North America, in the greater part of the world it remains the problem it has always been, one of a stigmatizing disease comparable to the modern day pestilence, namely AIDS.

Papers presented at the International Seminar on the Immunological System as a Target for Toxic Damage - Present Status, Open Problems and Future Perspectives

Proceedings of the Twenty-Fifth International Symposium on Blood Transfusion 2000, organized by the Blood Bank Noord Nederland

Papers of the Workshop on Thromboplastin Calibration Held in Leiden, The Netherlands, July 1, 1983

Papers presented at the International Seminar on the Immunological System as a Target for Toxic Damage - Present Status, Open Problems and Future Perspectives

Proceedings of the Fifteenth Annual Symposium on Blood Transfusion, Groningen 1990, organized by the Red Cross Blood Bank, Groningen-Drenthe

Proceedings of the Eighth Annual Symposium on Blood Transfusion, Groningen 1983, organized by the Red Cross Blood Bank Groningen-Drenthe

This book contains the proceedings of a symposium on the use of synthetic substrates in clinical blood coagulation assays, which was held at the University of Leuven, Belgium, on March 1st, 1980.

Yet, even if epidemiological studies clearly indicate the existence of an association between the amount of composition of dietary lipids and morbidity and mortality of cardio vascular disease, our basic knowledge on cause and effect is still hidden in a cloud of uncertainty.

The practice of transfusing blood started at the bedside but over the last few decades blood transfusion has become more and more a laboratory directed discipline. As a result of this separation clinical developments in blood transfusion may not have derived full benefit from the knowledge accrued in blood transfusion services.

Proceedings of the Seventh Annual Symposium on Blood Transfusion, Groningen, 1982, organized by the Red Cross Blood Bank Groningen-Drenthe

This book is an edited verbatim account of the proceedings of the Second London Workshop on Red Cell Filtration and Deformability, organised jointly by the Royal Society of Medicine and the Groupe de Travail sur la Filtration Erythrocytaire.

Proceedings of the Ninth Annual Symposium on Blood Transfusion, Groningen 1984, organized by the Red Cross Blood Bank Groningen-Drenthe

Proceedings of the Tenth Annual Symposium on Blood Transfusion, Groningen 1985, organized by the Red Cross Blood Bank Groningen-Drenthe

Proceedings of the Eleventh Annual Symposium on Blood Transfusion, Groningen 1986, organized by the Red Cross Blood Bank Groningen-Drenthe

Although leprosy is mainly known as an "import" disease in Europe and North America, in the greater part of the world it remains the problem it has always been, one of a stigmatizing disease comparable to the modern day pestilence, namely AIDS.

MUMPS VACCINE . . . . . . . Abnormal-toxicity test 98 7. . . . . . . . Test for residual live virus 99 7. Tests for extraneous agents 100 7. Test for Mycobacterium tuberculosis . . . . . Test for extraneous viruses 100 7. . . . . 100 XII 7 . Potency test . . . . . . . Test for abnormal toxicity 102 7. Test for extraneous agents 103 7.

Proceedings of the Twelfth Annual Symposium on Blood Transfusion, Groningen 1987, organized by the Red Cross Blood Bank, Groningen-Drenthe

That umbilical cord blood could be a significant source of allogeneic stem cells in related and unrelated transplantation is illustrated by the increasing number of cord blood banks in Europe and elsewhere.