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Proceedings of a Conference held in Sendai, Japan, August 14-18, 1990

The International Conference "e;Algebraic Geometry and Analytic Geometry, Tokyo 1990"e; was held at Tokyo Metropolitan University and the Tokyo Training Center of Daihyaku Mutual Life Insurance Co., from August 13 through August 17, 1990, under the co-sponsorship of the Mathematical Society of Japan. It was one of the satellite conferences of ICM90, Kyoto, and approximately 300 participants, including more than 100 from overseas, attended the conference. The academic program was divided into two parts, the morning sessions and the afternoon sessions. The morning sessions were held at Tokyo Metropolitan University, and two one-hour plenary lectures were delivered every day. The afternoon sessions at the Tokyo Training Center, intended for a more specialized audience, consisted of four separate subsessions: Arithemetic Geometry, Algebraic Geometry, Analytic Geometry I and Analytic Geometry II. This book contains papers which grew out of the talks at the conference. The committee in charge of the organization and program consisted of A. Fujiki, K. Kato, T. Katsura, Y. Kawamata, Y. Miyaoka, S. Mori, K. Saito, N. Sasakura, T. Suwa and K. Watanabe. We would like to take this opportunity to thank the many mathematicians and students who cooperated to make the conference possible, especially Professors T. Fukui, S. Ishii, Y. Kitaoka, M. Miyanishi, Y. Namikawa, T. Oda, F. Sakai and T. Shioda for their valuable advice and assistance in organizing this conference. Financial support was mainly provided by personal contributions from Professors M.

The Asia Simulation Conference 2006 (JSST 2006) was aimed at exploring challenges in methodologies for modeling, control and computation in simu- lation, and their applications in social, economic, and financial fields as well as established scientific and engineering solutions. The conference was held in Tokyo from October 30 to November 1, 2006, and included keynote speeches presented by technology and industry leaders, technical sessions, organized sessions, poster sessions, and vendor exhibits. It was the seventh annual inter- national conference on system simulation and scientific computing, which is organized by the Japan Society for Simulation Technology (JSST), the Chi- nese Association for System Simulation (CASS), and the Korea Society for Simulation (KSS). For the conference, all submitted papers were refereed by the international technical program committee, each paper receiving at least two independent reviews. After careful reviews by the committee, 65 papers from 143 submis- sions were selected for oral presentation. This volume includes the keynote speakers' papers along with the papers presented at the oral sessions and the organized sessions. As a result, we are publishing 87 papers for the conference in this volume. In addition to the scientific tracts presented, the conference featured keynote presentations by five invited speakers. We are grateful to them for accepting our invitation and for their presentations. We also would like to express our gratitude to all contributors, reviewers, technical program conmiittee members, and organizing committee members who made the conference very successful.

Financial fluctuations were generally neglected in classical ecnomics and their basic statistical properties have only recently been elucidated in the emerging field of econophysics, a new science that analyzes data using methods developed by statistical physics, such as chaos, fractals, and phase transitions. This volume is the proceedings of a workshop at which leading international researchers in this discipline discussed their most recent results and examined the validity of the empirical laws of econophysics. Topics include stock market prices and foreign exchange rates, income distribution, market anomalies, and risk management. The papers herein relate econophysics to other models, present new models, and illustrate the mechanisms by which financial fluctuations occur using actual financial data. Containing the most recent econophysics results, this volume will serve as an indispensable reference for economic theorists and practitioners alike.

The most recent research findings on the important genes, key molecules, and mechanisms in neural development and regeneration are presented in this volume. The papers collected here were delivered at the second of the Keio University International Symposia for Life Sciences and Medicine, held in Mita (Tokyo), Japan, and are in eight main sections: Early Neurogenesis and Pattern Formation, Regional and Cellular Specification, Trophic Factors, Adhesion Molecules, Glial Cell Lineage and Myelination, Circuit Formation, Synaptic Refinement and Neurotransmitter Release, and Neural Regeneration. Together, they present the concept of neural development and regeneration and its vital importance at the frontiers of medical science today. Neural Development is an invaluable resource and reference for researchers, clinicians, and students in physiology and the medical sciences.

Global warming poses a serious threat to the quality of life in the 21st century. Taking Japan as an example, this book explains the anticipated impact of global warming on modern society-natural ecosystems; agriculture, forestry, and fisheries; water resources and environments; the infrastructure and socioeconomic system; and human health. The most recent scientific and technical information is presented by more than 30 prominent researchers who are assessing the potential impact of global warming on nature and society. The results of their research provide dramatic evidence of the urgency of the task faced by policy makers in responding to climate change. For scientists and government officials alike, this volume may be considered required reading.

The importance of the therapeutic time window for ischemic stroke has been widely accepted for a long time. Consequently, I have been thinking about the past, when the term "e;brain attack,"e; which was reimported from the United States, began to spread by repetition. In the 1980s, I had made an enthusiastic study of acute-phase cerebral revascularization for ischemic stroke. At that time, we could cure only a quite lim- ited number of patients, such as those who already were hospitalized or who, fortu- nately, were brought to the hospital within a few hours from the onset of the stroke. RM Crowell, in his 1977 report! on cases of failure, had identified the consider- able problems in acute-phase cerebral revascularization as diagnosis of tissue reversibility, brain-protective reagents or methods, and effective techniques for revascularization. I remember that we strongly endorsed his opinion. Recently, the basic study of stroke has advanced significantly, resulting in newly developed materials and new experimental techniques, which are introduced in this book. I hope that new basic knowledge will be clinically applied.

Recent clinical trials of adjuvant therapy for gastric cancer in Japan have shown improved survival benefits, but the results have been considered controversial and have been viewed with some skepticism in the West. Until now, the efforts of Japanese surgical oncologists in multimodality therapy have not been fully understood because they have not been adequately reported in English. This volume now presents the experience and expertise of Japanese surgeons who utilize preoperative or intraoperative chemotherapy, or a combination of systemic and regional chemotherapy. Their collected work provides valuable insight in the Japanese perspective and success in treating gastric cancer. Included in the appendix is an extensive tabular analysis of the gastric cancer database at the Cancer Institute Hospital of Tokyo. Probably the largest such database in the world from a single institution, the analyses present the state of the art in treatment of gastric cancer.

The aging of society is a growing concern in all advanced nations, and at the forefront of concern is long-term care for frail older people. Enactment of a new public long-term care insurance program by the Japanese government in 1997 provided an excellent opportunity for a conference focusing on an ideal long-term care system for frail older people. The conference was organized around four major themes: Social aspects, including family dynamics and the role of formal providers; Clinical aspects, including effective treatments for physical and mental disabilities; Macroeconomic and macropolitical settings for public policy; Program design and management issues. With contributions from the fields of medicine, nursing, social work, gerontology, political science, economics, and sociology, this volume provides an overview of key problems and possible solutions in programs for frail older people from a unique international perspective.

Air pollution is ubiquitous in industrialized societies, causing a host of environmental problems. It is thus essential to monitor and reduce pollution levels. A number of plant species already are being exploited as detectors (for phytomonitoring) and as scavengers (for phytoremediation) of air pollutants. With advances in biotechnology, it is now feasible to modify plants for a wider range of phytomonitoring and phytoremediation applications. Air Pollution and Plant Biotechnology presents recent results in this field, including plant responses during phytomonitoring, pollution-resistant plant species, imaging diagnosis of plant responses, and the use of novel transgenic plants, along with reviews of basic plant physiology and biochemistry where appropriate. Researchers and students working in plant biotechnology and the environmental sciences or considering new areas of investigation will find this volume a valuable reference.

Because stroke is essentially a disease of the vessels and blood flow, the most fundamental aspects of ischemic blood flow in the brain are under investigation by researchers. Their work was the focus of the sixth in the series of Keio University International Symposia for Life Sciences and Medicine, held in Tokyo in 1999. Selected here are 55 papers from the symposium, covering the buffy coat (glycocalyx) of endothelial cells, the blood-brain barrier and permeability, gene expression, vascular reactivity, dysregulation, inflammatory deterioration, cortical spreading depression, edema, microvascular derangement, and pathology, in ten major sections. The book includes the thought-provoking discussions that followed the presentations, thus providing an invaluable source of up-to-date information not only for researchers investigating microcirculation but also for clinicians implementing the most effective treatment for stroke patients.

Rapid progress in technology and its application to diagnosis and monitoring of brain tissue temperature and metabolism have resulted in advances in the therapy for critically brain-injured patients and breakthroughs in understanding the pathophysiology of brain damage. The latest concept of brain hypothermia therapy clarifies targets such as brain thermal pooling, masking brain hypoxia associated with catecholamine surge, the metabolic shift from glucose to lipids, and selective radical damage of dopamine in the central nervous system. This volume explains the mechanism of brain injury and how brain hypothermia treatment differs from other hypothermia therapy in four major sections: Brain Injury Mechanism, Pathophysiology of Hypothermia, Basic Research of Hypothermia Treatment, and Clinical Studies of Brain Hypothermia. The book is a valuable source for practitioners and researchers in neurosurgery and neurology and in critical care and emergency medicine.

This book provides a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in molecular bases and targeted therapy for this neoplasm. The remarkable resistance to chemotherapy and radiotherapy and the minimum contribution of cancer genes that commonly mutate in other adult epithelial cancers have made RCC highly distinct from other types of solid neoplasms. In the past decade, however, treatment options for RCC have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. Advances in RCC therapy also have brought novel treatment options to other types of cancer, such as a TKI for hepatocellular carcinoma and gastrointestinal tumors, as well as mTOR inhibitors to progressive neuroendocrine tumors of pancreatic origin and to breast cancer, suggesting that RCC is no longer an "orphan disease" in the field of molecular oncology. Additional topics covered in the book include pharmacokinetics and pharmacodynamics in molecular-targeted agents and the putative mechanism of resistance to anti-angiogenic agents, such as intratumoral heterogeneity or cancer stem cell population. This volume provides the latest and most useful information for all readers who are eagerly devoted to curing renal cell carcinoma.

This book presents a thorough review of coronary angioscopy, ranging from instructions on its use to the latest advances. Starting with the structure and fundamental principles of angioscopy, it shows readers how to apply the image to comprehensive care of coronary-artery patients. Plentiful color photos and illustrations will enable readers to investigate and classify plaques and thrombi and to evaluate coronary stent- and drug-based therapies. The authors are leading researchers on angioscopy. This book offers the perfect guide not only for new clinicians but also for cardiologists who have already adopted this technique for medical examination and treatment. Angioscopy is a unique medical technique for visualizing the interior of blood vessels and helps physicians not only to diagnose the pathology but also to measure the effectiveness of Percutaneous coronary intervention (PCI) or antiarteriosclerotic drugs. Furthermore, the recently developed molecular angioscopy approach allows us to observe Low-density lipoprotein (LDL) oxide, collagen, and macrophages, and is rapidly growing in importance.

The Tohoku University Graduate School of Dentistry first introduced the concept of "e;Interface Oral Health Science"e;, designed to establish and maintain healthy oral cavities, which are home to a number of mixed systems. Included in those systems are: (1) host tissues such as teeth, mucosa, muscle and bone, (2) parasites and microorganisms cohabiting the surfaces of the oral cavity and (3) biomaterials that are used for the rehabilitation of oral functions. In addition, (4) these systems are subject to severe and complex mechanical forces. Therefore, it is critical to promote dental studies that integrate a wide range of interdisciplinary research as medicine, agriculture, material science, engineering, and pharmacology. With this incentive, international symposiums for interface oral health science have been held several times in the past. The concept has since refined and expanded, the result being the "e;Biosis-Abiosis Intelligent Interface,"e; and projects aiming at the creation of highly functional and autonomic intelligent interfaces are ongoing. This book brings together a number of studies on incentives and projects by leading authors. Topics include biosis-abiosis interface of dental implants, biomaterials in interface science, biomedical engineering interface and cell manipulation and tissue regeneration. Readers not only from the field of dentistry but also many related areas will find this book a valuable resource.

The purpose of this publication is to elucidate the biological aspect of the abiotic stress response from the field to the molecular level in horticultural plants. This book is unique in that it concerns the basic aspect of abiotic stress biology and research progress at the molecular level in model plants or major field crops, as it focuses mainly on the abiotic stress response in existing horticultural plants. Many readers interested in plant abiotic stress biology are aware of the application of the latest findings to agricultural production, and this book will have a special appeal for those readers. The book will be of interest to scientists and graduate students who are involved in the research, development, production, processing, and marketing of horticultural products, including those in developing countries who are interested in high tech and advanced science in this field. The application of the latest findings to agricultural production is particularly useful.Stress tolerance mechanisms in horticultural crops are gaining importance, because most agricultural regions are predicted to experience considerably more extreme environmental fluctuations due to global climate change. Further, because of recent progress in next-generation sequencing technologies, the postgenomic era is impending not only in model plants and major cereal crops but also in horticultural crops, which comprise a great diversity of species. This book provides information on the physiological aspects of the abiotic stress response in horticultural plants, which is considered essential for postgenomic research.

Autoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC. AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease. Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries.

This book highlights recent advances in natural computing, including biology and its theory, bio-inspired computing, computational aesthetics, computational models and theories, computing with natural media, philosophy of natural computing and educational technology. It presents extended versions of the best papers selected from the symposium "7th International Workshop on Natural Computing" (IWNC7), held in Tokyo, Japan, in 2013.The target audience is not limited to researchers working in natural computing but also those active in biological engineering, fine/media art design, aesthetics and philosophy.

Japan is a country lacking her own energy sources and other natural resource~. Still, over the 4 decades since the end of World War II, she has achieved considerable economic development, a fact which highlights the success of the policies implemented by the government and their acceptance by the well matured Japanese society. At present, the world is confronted with serious environmental problems, for example, the consumption of large amounts of energy that leads to in­ creases in atmospheric carbon dioxide levels anq subsequent global warming. After the oil crisis in the 1970s, Japan strove to reduce energy consumption, and achieved significant improvements in production efficiency in industry and in the air conditioning of homes. Another example of her success is in the automobile industry, where Japanese automobiles enjoy a good reputation for fuel efficiency. Japan has shown that environmental protection and economic development can be accomplished simultaneously, although the problems have not been solved completely. There are many areas that require further study. In this book, Dr. Helmar Krupp describes how society is organized to form a system. Then, in a unique and interesting turn, he tries to analyze the indus­ trial development using Schumpeter's theory. Subsequently, many leaders in the field of energy policy in Japan discuss the issues involved from a variety of viewpoints.

Diversity is characteristic of the information age and also of statistics. To date, the social sciences have contributed greatly to the development of handling data under the rubric of measurement, while the statistical sciences have made phenomenal advances in theory and algorithms. Measurement and Multivariate Analysis promotes an effective interplay between those two realms of research-diversity with unity. The union and the intersection of those two areas of interest are reflected in the papers in this book, drawn from an international conference in Banff, Canada, with participants from 15 countries. In five major categories - scaling, structural analysis, statistical inference, algorithms, and data analysis - readers will find a rich variety of topics of current interest in the extended statistical community.