Bøger i Molecular Biology Intelligence Unit serien

Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states.

Recent advances in genomic sequencing provide the background for analysis of polymorphic sites in large chromosomal regions or even in whole genome, thus providing the tool for effective identification of loci that are under strong pressure of positive selection.

Recent advances in genomic sequencing provide the background for analysis of polymorphic sites in large chromosomal regions or even in whole genome, thus providing the tool for effective identification of loci that are under strong pressure of positive selection.

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

This book provides information on the molecular interactions between host cell organelles and pathogens, which have developed strategies to survive within infected cells. Host response. Host cells are able to react against intruders and eventually mount host responses.

Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins.

Eukaryotic DNA Damage Surveillance and Repair contains chapters from experts in the field of DNA damage detection, repair, and cell cycle control.

The B7-CD28 family molecules are probably the most intensively studied receptor-ligand systems in the field of immunology. This book covers significant territory of this rapidly moving field from structural biology and biochemical signalling to immunological functions and their potential applications in the treatment of human diseases.

This book will be of undoubted value to biomedical students and teachers, as well as those actively engaged in research on cholesterol metabolism, cancer, and atherosclerosis.

Viral Genome Packaging focuses on the process of genome "packaging" within a pre-formed viral procapsid. The chapters of this book concentrate on the biochemistry, enzymology and structural aspects of the genome packaging machinery. The biochemical, biophysical and structural aspects of genome packaging are examined in detail.

Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era.

The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine.

The Annexins is focused on a specific family of calcium and membrane-binding proteins, annexins, ubiquitously spread within living organisms, including animals, plants and fungi.

Compiles the fruits of the studies that have been performed to solve the riddle written in DNA conformation. This book provides a comprehensive overview of the field by covering history of the field, topics, clarifications of research, and future perspective. It serves as a useful source of information on the "conformation code".

Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.

Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.

Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling.

The purpose of E-Cell System: Basic Concepts and Applications is to provide a comprehensive guide for the E-Cell System version 3 in terms of the software features and its usage.

The B7-CD28 family molecules are probably the most intensively studied receptor-ligand systems in the field of immunology. This book covers significant territory of this rapidly moving field from structural biology and biochemical signalling to immunological functions and their potential applications in the treatment of human diseases.

This volume provides broad insights to the most recent discoveries in telomere biology, with current applications in tumor diagnostics and future potentials in therapy. This book will be a core reference for any physician, scientist or "educated reader" with an interest in the exciting developments in this research field.

Comprises 19 chapters written by leading international experts in the field. Also, bibliography is given in each chapter.

Presenting key ideas in the field, this volume explores how transgenics have been used to study p53. The text explores how clinical genetics have identified and mutations in p53 found in human cancers, and how p53 can be regulated by post-translational modification.

The Networking of Chaperones by Co-chaperones updates the current understanding of how chaperones are regulated and networked. It is a resource for those in the specialized field of cell stress and chaperones. The book will also be of interest to those in broader cross-cutting field such as cellular networks and systems biology.

Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.

The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland.

Since its first discovery in the early 90's, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease.

This book addresses the most recent advances in the transport of proteins across a variety of biological membranes.